2010 Fiscal Year Final Research Report
Effect of adipocytokines on periodontal regeneration
| Project/Area Number |
20592441
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Osaka Dental University |
|---|
Principal Investigator |
KAMADA Aiko Osaka Dental University, 歯学部, 准教授 (50140215)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Joji 大阪歯科大学, 歯学部, 教授 (80169094)
IKEO Takashi 大阪歯科大学, 歯学部, 教授 (40159603)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 再生医学 / 歯学 / 硬組織 / アディポカイン |
|---|
| Research Abstract |
In order to apply adipocyte-derived biologically active molecules to tissue engineering, we investigated effect of adipocytokine on periodontal tissues. It was demonstrated that adiponectin, abundant adipocytokine, influenced to the tissues directly, and the failure of adiponectin action suppressed the progression of osteoblast differentiation. Therefore, low plasma adiponectin levels may cause not only insulin resistance and metabolic syndrome but also delay of bone formation.
|
