2010 Fiscal Year Final Research Report
Investigation of effect of soluble factors from adipose tissue on periodontitis, and development of prophylactic approach with these regulation
| Project/Area Number |
20592457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
AKIFUSA Sumio Kyushu University, 歯学研究院, 准教授 (40295861)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Yoshihisa 九州大学, 大学院・歯学研究院, 教授 (20192403)
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| Project Period (FY) |
2008 – 2010
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| Keywords | メタボリックシンドローム / 歯周疾患 / 肥満 |
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| Research Abstract |
We examined the effect of adiponectin, one of adipokine derived from mature adipocyte, on activity of macrophage, and found that administration of adiponectin reduced the lipopolysaccharide-induced inflammatory response. On the other hand, stimulation with adiponectin alone induced cytokine secretion, generation of reactive oxygen species and nitric oxide, followed by apoptotic cell death, in macrophage.
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