2010 Fiscal Year Final Research Report

Development of protection for systemic and oral infection by control of oral microbes.

Research Project

Project/Area Number	20592460
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Social dentistry
Research Institution	Kagoshima University
Principal Investigator	YAMAGUCHI Taihei Kagoshima University, 医歯学総合研究科, 准教授 (80230358)
Co-Investigator(Kenkyū-buntansha)	OHO TAKAHITO 鹿児島大学, 医歯学総合研究科, 教授 (50160940) SOUTOME Sakiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (20325799)
Project Period (FY)	2008 – 2010
Keywords	口腔常在菌 / 唾液 / 凝集 / 付着 / 凝集素 / カルシウム
Research Abstract	Streptococcus intermedius is an oral commensal and a cause of systemic pyogenic disease. A part of the organism possessed curly-like fimbriae. Genomic analyses showed that the operon of the fimbriae was a typical pilus gene operon and constructed of at least 4 ORFs. A fimI was predicted to be the structural subunit encoding the 486-amino acid protein, FimI. Strains of the Streptococcus anginosus group containing the fimI gene were restricted to serotype g and untypable,. Knockout mutants within fimI did not participate in saliva-mediated aggregation either. The adherent activity of mutants toward plastic wells coated with salivary agglutinin was about 65% that of the parent strain.

(4 results)