2010 Fiscal Year Final Research Report
Development of a Periodontal Disease Screening System Using Biomarkers in Saliva
| Project/Area Number |
20592461
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
SOH Inho Kyushu Dental College, 歯学部, 助教 (10285463)
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| Co-Investigator(Kenkyū-buntansha) |
ANSAI Toshihiro 九州歯科大学, 歯学部, 准教授 (80244789)
AWANO Syuuji 九州歯科大学, 歯学部, 講師 (20301442)
YOSHIDA Akihiro 九州歯科大学, 歯学部, 助教 (20364151)
TAKATA Yutaka 九州歯科大学, 歯学部, 教授 (40163208)
SONOKI Kazuo 九州歯科大学, 歯学部, 准教授 (50316155)
INENAGA Kiyotoshi 九州歯科大学, 歯学部, 教授 (90131903)
TAKEHARA Tadamichi 九州歯科大学, 歯学部, 名誉教授 (00038879)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯周病 / ストレス評価 / 唾液検査 / QOL評価 / ホルモン |
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| Research Abstract |
Recent studies have found a positive relationship between periodontitis and the hormones cortisol and dehydroepiandrosterone (DHEA). We investigated the associations between periodontitis and the cortisol and DHEA levels in elderly never-smokers and smokers. The cortisol and DHEA levels in saliva were determined, together with the probing depth (PD) and clinical attachment loss (CAL), in 171 subjects (85 males, 86 females). Smoking affected the cortisol and DHEA levels, which were significantly associated with severe PD and CAL in never-smokers. According to the ROC analysis, the respective cutoff values for cortisol and DHEA that gave the optimal sensitivity and specificity for detecting severe periodontitis were 2.06ng/mL and 60.24pg/mL for PD and 2.12ng/mL and 61.78pg/mL for CAL. An assessment of hormone levels may be a useful screening method for periodontitis, although its utility is limited to never-smokers.
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[Journal Article] Salivary levels of cortisol and chromogranin A in patients with dry mouth compared to age-matched controls.2008
Author(s)
Shigeyama, C., Ansai, T., Awano, s., Soh, I.(他6名4番目)
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 106
Pages: 833-839
Peer Reviewed
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[Journal Article] Determination of cortisol and dehydroepiandrosterone levels in saliva for screening of periodontitis in older Japanese adults.
Author(s)
Ansai, T., Soh, I., Ishisaka, A., Yoshida, A., Awano, S., Hamasaki, T., Sonoki, K., Takata, Y., Takehara, T.
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Journal Title
Int J Dent Article ID 280737 Vol.2009
Pages: 8
Peer Reviewed
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