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2010 Fiscal Year Final Research Report

Elucidation of relationship between indole produced in periodontopathogenic bacteria and periodontal disease

Research Project

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Project/Area Number 20592463
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionIwate Medical University

Principal Investigator

YOSHIDA Yasuo  Iwate Medical University, 歯学部, 准教授 (10315096)

Co-Investigator(Kenkyū-buntansha) 岸 光男  岩手医科大学, 歯学部, 准教授 (60295988)
帖佐 直幸  岩手医科大学, 歯学部, 助教 (80326694)
中野 善夫  日本大学, 歯学部, 准教授 (80253459)
Project Period (FY) 2008 – 2010
Keywordsインドール / 歯周病細菌 / バイオフィルム
Research Abstract

To elucidate the molecular mechanism to produce indole in Porphyromonas gingivalis、Fusobacterium nucleatum, and Prevotella intermedia, we carried out the transcriptional analyses of tnaA encoding tryptophanase associated with indole production and enzymatic characterization of the purified protein. We also clarified induction of F. nucleatum biofilm formation by indole. In addition, tryptophan that is a substrate for indole production was also suggested to promote biofilm formation of the microorganism.

  • Research Products

    (17 results)

All 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] The inhibitory effects of mushroom extracts on sucrose-dependent oral biofilm formation.2010

    • Author(s)
      A.Yano, S.Kikuchi, Y.Yamashita, Y.Sakamoto, Y.Nakagawa, Y.Yoshida
    • Journal Title

      Appl.Microbiol.Biot. 86

      Pages: 615-623

    • Peer Reviewed
  • [Journal Article] Use of a novel assay to evaluate enzymes that produce hydrogen sulfide in Fusobacterium nucleatum.2010

    • Author(s)
      Y.Yoshida, S.Ito, H.Tamura, K.Kunimatsu
    • Journal Title

      J.Microbiol.Meth. 80

      Pages: 313-315

    • Peer Reviewed
  • [Journal Article] Production of indole from L-tryptophan and their effects on biofilm formation by Fusobacterium nucleatum ATCC 25586.2010

    • Author(s)
      T.Sasaki-Imamura, A.Yano, Y.Yoshida
    • Journal Title

      Appl.Environ.Microbiol. 76

      Pages: 4260-4268

    • Peer Reviewed
  • [Journal Article] Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine in Fusobacterium nucleatum subsp. nucleatum ATCC 25586.2010

    • Author(s)
      Y.Yoshida, S.Ito, M.Kamo, Y.Kezuka, H.Tamura, K.Kunimatsu, H.Kato
    • Journal Title

      Microbiology-SGM 156

      Pages: 2260-2269

    • Peer Reviewed
  • [Journal Article] Identification and characterization of an autolysin gene, atlh, from Streptococcus downei.2009

    • Author(s)
      H.Tamura, A.Yamada, Y.Yoshida, H.Kato
    • Journal Title

      Curr.Microbiol. 58

      Pages: 432-437

    • Peer Reviewed
  • [Journal Article] Identification and molecular characterization of tryptophanase encoded by tnaA in Porphyromonas gingivalis.2009

    • Author(s)
      Y.Yoshida, T.Sasaki, S.Ito, H.Tamura, K.Kunimatsu, H.Kato
    • Journal Title

      Microbiology-SGM 155

      Pages: 968-978

    • Peer Reviewed
  • [Journal Article] Comparative structural and molecular characterization of ribitol-5-phosphate-containing Streptococcus oralis coaggregation receptor polysaccharides.2009

    • Author(s)
      J.Yang, M.Ritchey, Y.Yoshida, C.A.Bush, J.O.Cisar.
    • Journal Title

      J.Bacteriol. 191

      Pages: 1891-1900

    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray analysis of C-S lyases from two oral streptococci.2009

    • Author(s)
      Y.Kezuka, Y.Yoshida, T.Nonaka
    • Journal Title

      Acta.Crystallogr.Sect.F Struct.Biol.Cryst.Commun. F65

      Pages: 874-877

    • Peer Reviewed
  • [Presentation] Identification and characterization of novel enzymes associated with hydrogen sulfide production in Fusobacterium nucleatum2010

    • Author(s)
      K.Suwabe, Y.Yoshida, D.Sasaki, F.Yoshimura, K.Kunimatsu
    • Organizer
      50^<th> General Session and 1^<st> International Congress of the KAP
    • Place of Presentation
      Seoul
    • Year and Date
      20101100
  • [Presentation] Prevotella intermedia ATCC 25611におけるインドール産生能の解明2010

    • Author(s)
      今村隆子、吉田康夫、加藤裕久
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      20100900
  • [Presentation] Production of indole that increases biofilm formation of Fusobacterium nucleatum2010

    • Author(s)
      T.Sasaki-Imamura, Y.Yoshida, A.Yano, H.Kato
    • Organizer
      88^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Barcelona
    • Year and Date
      20100600
  • [Presentation] カテキンによる揮発性硫化物の抑制効果2010

    • Author(s)
      伊東俊太郎、吉田康夫、須和部京介、國松和司
    • Organizer
      第53回春季日本歯周病学会学術大会
    • Place of Presentation
      盛岡
    • Year and Date
      20100500
  • [Presentation] Fusobacterium nucleatumにおいてシステイン合成酵素は硫化水素産生に関与する2010

    • Author(s)
      須和部京介、吉田康夫、伊東俊太郎、田村晴希、國松和司、加藤裕久
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20100300
  • [Presentation] Fusobacterium nucleatumのインドール産生能の解明2009

    • Author(s)
      佐々木隆子、吉田康夫、田村晴希、加藤裕久
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      20090900
  • [Presentation] Fusobacterium nucleatumにおける2つの硫化水素産生酵素2009

    • Author(s)
      伊東俊太郎、吉田康夫、田村晴希、須和部京介、國松和司、加藤裕久
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      20090900
  • [Presentation] Molybdenum ion inhibits the production of volatile sulfur compounds.2009

    • Author(s)
      S.Ito, Y.Yoshida, T.Sasaki, K.Kunimatu, H.Kato
    • Organizer
      87^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Miami, USA.
    • Year and Date
      20090400
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2017-10-13  

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