2010 Fiscal Year Final Research Report
Analysis of virulent mechanism of periodontal pathogen that invades in the mucosal epithelium cells and of effect of antibiotics on the invaded bacterium.
| Project/Area Number |
20592466
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
TAKESHITA Akira Meikai University, 歯学部, 准教授 (70236454)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯周炎 / 歯周病原性細菌 / 細胞内侵入 / Porphyromonas gingivalis / IL-6 / 炎症性サイトカイン |
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| Research Abstract |
Although it has been demonstrated that the periodontal disease pathogen Porphyromonas gingivalis is able to invade into various types of cell in the periodontal tissue including oral mucosal epithelial cells, there are few studies that examine whether the bacterial invasion contribute to the pathogenic mechanisms involved in the lead of the exacerbation of the disease. Then, we have investigated the effect of the bacterial invasion on the human mucosal epithelial cell line KB cells in this study. Therefore, this study showed that the bacterial invasion is able to induce the expression of IL-6 in the cells.
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[Journal Article] Porphyromonas gingivalis線毛はマウス単球性骨髄性白血病細胞株M1細胞のアポトーシスを抑制する2011
Author(s)
竹下玲, 江端淳, 末續真弓, 流石知佳, 中川和弘, 小山主之, 田中園治, 遠藤浩正, 田中入, 柏崎秀一, 熊倉学, 元治茂樹, 大高義文, 杉山卓司, 佐藤豊, 河野哲, 川俣富貴子, 佐藤淑郎, 中林靖雄, 中筋宣子, 杉山義祥, 深井智子, 安井利一
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Journal Title
明海歯科医学 Vol.40
Pages: 67-83
Peer Reviewed
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[Journal Article] マウスマクロファージ様細胞株RAW264.7細胞における一酸化窒素誘導性細胞死に対する酪酸の抗アポトーシス作用2009
Author(s)
高野安紀子, 竹下玲, 末續真弓, 篠田寛幸, 松本健, 永井明子, 岡安麻里, 大井迪, 長谷川紘也, 土居孝資, 桃井知子, 高橋明子, 安井利一, 鐘ヶ江晴秀
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Journal Title
明海歯科医学 Vol.38
Pages: 151-165
Peer Reviewed
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