2010 Fiscal Year Final Research Report
Development of apical tissue regeneration technology using human tooth germ derived cloning cell
| Project/Area Number |
20599002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
IKEDA Etsuko Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (20509012)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Teruko 東北大学, 大学院・歯学研究科, 教授 (00127250)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJI Takashi 東京理科大学, 総合研究機構, 教授 (50339131)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯根吸収 / 矯正治療 / ヒト歯胚 / 歯根尖部再生技術 |
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| Research Abstract |
We aimed to develop apical tissue regeneration technology to restore root length that was lost due to root resorption or surgical root resection in the orthodontic treatment. As a result, we successfully reconstituted a bioengineered tooth germ for eruption using the organ germ method. We developed an animal model that reproduces root apical tissue regeneration and used this model to transplant the apical tissue from the bioengineered tooth germ, but were unable to observe engraftment of the tissue. Then, for the stabilization of the engraftment, I aimed at the transplant of the bioengineered tooth root of the same size. Currently, our experiments are ongoing to transplant the apical tissue from the bioengineered tooth of the same size, which was developed by transplantation in the sub-renal capsule, into the animal model.
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