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2010 Fiscal Year Final Research Report

Role of phosphatidylinositols in the pathogenesis of severe respiratory failure

Research Project

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Project/Area Number 20599003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionAkita University

Principal Investigator

IMAI Yumiko  Akita University, 大学院・医学系研究科, 教授 (50231163)

Co-Investigator(Renkei-kenkyūsha) SASAKI Takehiko  秋田大学, 大学院・医学系研究科, 教授 (50333365)
SASAKI Junko  秋田大学, 大学院・医学系研究科, 講師 (30333371)
TAKASUGA Shunsuke  秋田大学, 大学院・医学系研究科, 助教 (90375262)
EGUCHI Satoshi  秋田大学, 大学院・医学系研究科, 助教 (70457117)
OHTEKI Toshiaki  東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
Project Period (FY) 2008 – 2010
Keywords集中治療 / 呼吸不全 / ウイルス感染症 / 細胞膜イノシトールリン脂質
Research Abstract

The acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), is triggered by various pathogenic conditions including sepsis, gastric acid aspiration, trauma, or infection with various viruses (SARS-coronavirus, H5N1 avian influenza, or novel swine-origin 2009 H1N1 influenza). No effective drugs have been proven to improve clinical outcomes in ARDS. Considering its high lethality and the threats of influenza pandemics, it is crucial to identify novel therapeutic targets for ARDS. In the present study, using mouse ICU model system, we examined the role of phosphatidylinositol pathway in the pathogenesis of ARDS. We found that endosomal PIs, in particular class III PI3-kinase was involved in the pathogenesis of ARDS with non-viral and viral origins.

  • Research Products

    (27 results)

All 2010 2009 2008 Other

All Journal Article (16 results) (of which Peer Reviewed: 9 results) Presentation (9 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Trilogy of ACE2 : a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters.2010

    • Author(s)
      Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM.
    • Journal Title

      Pharmacol Ther. 128(1)

      Pages: 119-28

    • Peer Reviewed
  • [Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.2010

    • Author(s)
      Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.
    • Journal Title

      Cell. 141(1)

      Pages: 142-53

    • Peer Reviewed
  • [Journal Article] PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.2010

    • Author(s)
      Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B.
    • Journal Title

      PLoS One. 22,5(2)

      Pages: e9350

    • Peer Reviewed
  • [Journal Article] Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis.2010

    • Author(s)
      Imai Y, Kuba K, Ohto-Nakanishi T, Penninger JM.
    • Journal Title

      Circ J. 74(3)

      Pages: 405-10

    • Peer Reviewed
  • [Journal Article] ARDS発症機序解明の新たな展開2010

    • Author(s)
      今井由美子
    • Journal Title

      最新医学 66

      Pages: 505-510

  • [Journal Article] 宿主システムからのウイルス病原性発現機構解明へのアプローチ2010

    • Author(s)
      今井由美子, 他
    • Journal Title

      実験医学 28

      Pages: 2924-26

  • [Journal Article] 新興ウイルス感染症におけるARDS発症2010

    • Author(s)
      今井由美子, 他
    • Journal Title

      重症化の分子機構実験医学 28

      Pages: 2934-39

  • [Journal Article] 新型インフルエンザによるLI/ARDSの特徴は?2010

    • Author(s)
      今井由美子
    • Journal Title

      救急・集中治療 22

      Pages: 1114-1119

  • [Journal Article] 重症型インフルエンザの病態生理2010

    • Author(s)
      今井由美子
    • Journal Title

      人工呼吸 27

      Pages: 62-69

  • [Journal Article] ACE2と呼吸器疾患2010

    • Author(s)
      今井由美子, 他
    • Journal Title

      呼吸 9

      Pages: 1070-1074

  • [Journal Article] 新型インフルエンザとacute respiratory distress syndrome(ARDS)2010

    • Author(s)
      今井由美子, 他
    • Journal Title

      日本集中治療医学会誌 17

      Pages: 11-17

    • Peer Reviewed
  • [Journal Article] Further advances in immunity against highly pathogenic influenza viruses.2009

    • Author(s)
      今井由美子.
    • Journal Title

      European Infectious Disease. 3(1)

      Pages: 61-4

    • Peer Reviewed
  • [Journal Article] The role of ACE2 in pulmonary2009

    • Author(s)
      Oudit GY, Imai Y, Kuba K, Scholey JW, Penninger JM.
    • Journal Title

      diseases--relevance for the nephrologist. 24(5)

      Pages: 1362-5

    • Peer Reviewed
  • [Journal Article] インフルエンザによる呼吸2009

    • Author(s)
      今井由美子, 他
    • Journal Title

      不全の発症機構細胞 41(14)

      Pages: 8-11

  • [Journal Article] The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice.2008

    • Author(s)
      Imai Y, Kuba K, Penninger JM.
    • Journal Title

      Exp Physiol. 93(5)

      Pages: 543-8

    • Peer Reviewed
  • [Journal Article] Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.2008

    • Author(s)
      Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM.
    • Journal Title

      Cell. 18,133(2)

      Pages: 235-49

    • Peer Reviewed
  • [Presentation] Molecular pathogenesis of respiratory failure in influenza.2010

    • Author(s)
      今井由美子
    • Organizer
      BMB2010 Biochemistry and Molecular Biology
    • Place of Presentation
      神戸(シンポジウム)
    • Year and Date
      2010-12-07
  • [Presentation] Acute lung injury (ALI)/ARDS mediated by emerging respiratory virus infection.2010

    • Author(s)
      今井由美子
    • Organizer
      HKU-PASTEUR IMMUNOLOGY COURSE
    • Place of Presentation
      Hong Kong(招待講演)
    • Year and Date
      2010-11-05
  • [Presentation] 新型インフルエンザ2010

    • Author(s)
      今井由美子
    • Organizer
      呼吸療法医学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-07-24
  • [Presentation] 脂質メタボロミクスからみえてきたインフルエンザ重症化機構2010

    • Author(s)
      今井由美子
    • Organizer
      適応医学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-07-02
  • [Presentation] インフルエンザによる重症呼吸不全の病態2010

    • Author(s)
      今井由美子
    • Organizer
      集中治療学会近畿地方会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-06-22
  • [Presentation] Hyper-response of innate immune system triggered by oxidative stress and oxidized phospholipids controls the severity of acute lung injury.2010

    • Author(s)
      今井由美子
    • Organizer
      Keystone symposia
    • Place of Presentation
      京都
    • Year and Date
      2010-06-08
  • [Presentation] The role of TLR4 in influenza pathogenesis and ACE2 interventional therapy.2010

    • Author(s)
      今井由美子
    • Organizer
      Gordon conference satellite symposium ; Mechanisms of lung injury and immunomodulator interventions in influenza
    • Place of Presentation
      Ventura, USA(招待講演)
    • Year and Date
      2010-03-05
  • [Presentation] インフルエンザによる呼吸不全の病態と治療戦略2009

    • Author(s)
      今井由美子
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2009-06-03
  • [Presentation] The role of ACE2 in the pathogenesis of ALI : a therapeutic perspective.2009

    • Author(s)
      今井由美子
    • Organizer
      Korean Critical Care Medicine
    • Place of Presentation
      Soul, Korea(招待講演)
    • Year and Date
      2009-04-26
  • [Book] Pathogenesis of Ventilator-Induced Lung Injury, Physiological Basis of Ventilatory Support2009

    • Author(s)
      Valenza F, Frank JA, Imai Y, Slutsky AS.
    • Publisher
      Marcel Dekker Inc.
  • [Remarks] ホームページ等

    • URL

      http://www.med.akita-u.ac.jp/~yakuri/index.html

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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