2010 Fiscal Year Final Research Report
Role of phosphatidylinositols in the pathogenesis of severe respiratory failure
| Project/Area Number |
20599003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Akita University |
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Principal Investigator |
IMAI Yumiko Akita University, 大学院・医学系研究科, 教授 (50231163)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Takehiko 秋田大学, 大学院・医学系研究科, 教授 (50333365)
SASAKI Junko 秋田大学, 大学院・医学系研究科, 講師 (30333371)
TAKASUGA Shunsuke 秋田大学, 大学院・医学系研究科, 助教 (90375262)
EGUCHI Satoshi 秋田大学, 大学院・医学系研究科, 助教 (70457117)
OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 集中治療 / 呼吸不全 / ウイルス感染症 / 細胞膜イノシトールリン脂質 |
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| Research Abstract |
The acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), is triggered by various pathogenic conditions including sepsis, gastric acid aspiration, trauma, or infection with various viruses (SARS-coronavirus, H5N1 avian influenza, or novel swine-origin 2009 H1N1 influenza). No effective drugs have been proven to improve clinical outcomes in ARDS. Considering its high lethality and the threats of influenza pandemics, it is crucial to identify novel therapeutic targets for ARDS. In the present study, using mouse ICU model system, we examined the role of phosphatidylinositol pathway in the pathogenesis of ARDS. We found that endosomal PIs, in particular class III PI3-kinase was involved in the pathogenesis of ARDS with non-viral and viral origins.
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[Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.2010
Author(s)
Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.
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Journal Title
Cell. 141(1)
Pages: 142-53
Peer Reviewed
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[Journal Article] PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.2010
Author(s)
Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B.
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Journal Title
PLoS One. 22,5(2)
Pages: e9350
Peer Reviewed
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[Journal Article] Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.2008
Author(s)
Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM.
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Journal Title
Cell. 18,133(2)
Pages: 235-49
Peer Reviewed
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