2010 Fiscal Year Final Research Report
Involvement ofsphingosine-1-phosphate (S1P) in the pathogenesis of preeclampsia
| Project/Area Number |
20599006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya University |
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Principal Investigator |
KOTANI Tomomi Nagoya University, 医学部附属病院, 講師 (70359751)
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| Project Period (FY) |
2008 – 2010
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| Keywords | EVT / 脱落膜 / SphK / 細胞浸潤 / LPA |
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| Research Abstract |
The first step of the pathogenesis of preeclampsia is thought to be the failure of fetus extravillous trophoblasts (EVT) invasion into maternal desidua. It is suggested to be resulted in shallow placentaion, followed by intrauterine growth retardation. However, the molecular mechanisms remain unclear. In this study, we found that shingoshine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are main lysophospholipids known as a chemical mediator of cell proliferation and motility, would be involved in the invasion of EVT. These would be targets for the new therapy of preeclampsia.
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Research Products
(18 results)
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[Journal Article] Successful fertility management of a patient with factor V deficiency : planned transfusion of fresh frozen plasma under infertility treatment.2011
Author(s)
Iwase A, Goto M, Manabe S, Hirokawa W, Kobayashi H, Nakahara T, Takikawa S, Kotani T, Sumigama S, Tsuda H, Nakayama T, Suzuki N, Matsushita T, Kikkawa F.
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Journal Title
Fertil Steril. Epub ahead of print
Peer Reviewed
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[Journal Article] Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma.2010
Author(s)
Kotani T, Sumigama S, Hayakawa H, Mano Y, Tsuda H, Sugiyama C, Kawachi F, Hironaka M, Kato T, Kaneko K, Hayakawa M, Kikkawa F.
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Journal Title
Ultrasound Obstet Gynecol. 36(2)
Pages: 256-258
Peer Reviewed
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[Journal Article] Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells.2010
Author(s)
Morimitsu A, Sumigama S, Kotani T, Mano Y, Suzuki K, Araki-Taguchi M, Yamamoto E, Hayakawa H, Okada M, Itakura A, Kikkawa F.
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Journal Title
Gynecol Obstet Invest. 69(1)
Pages: 67-72
Peer Reviewed
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