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2010 Fiscal Year Final Research Report

Development of new tumor vaccines using antigen presentation by recycling MHC class II molecules

Research Project

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Project/Area Number 20599023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionDepartment of Clinical Research National Hospital Organization, National Sanyo Hospital

Principal Investigator

YUSUKE Mimura  Department of Clinical Research National Hospital Organization, National Sanyo Hospital, 臨床研究部, 生理生化学研究室長 (00219718)

Project Period (FY) 2008 – 2011
Keywords抗原認識
Research Abstract

Efficient antigen presentation to CD4+ T cells is essential for activation of anti-tumor immunity. In order to elicit robust T cell responses with smaller doses of antigen, we have designed a new vaccine in which a CD4+ T cell epitope of ovalbumin is inserted in the complementary determining region of an immunoglobulin molecule. This inserted epitope is supposed to be presented to CD4+ T cells after direct binding to a recycling MHC class II molecule on the surface of an antigen presenting cell and processing in the endosome, in contrast to the known processing pathway involving the late endosomes and lysosomes.

  • Research Products

    (8 results)

All 2011 2010 2009 2008 Other

All Journal Article (3 results) Presentation (3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells.2011

    • Author(s)
      Tao, H, Mimura, Y, Aoe, K, Kobayashi, S, Yamamoto, H, Matsuda, E, Okabe, K, Matsumoto, T, Sugi, K, Ueoka, H
    • Journal Title

      Lung Cancer in press

  • [Journal Article] Identification of cancer stem cell markers in human malignant mesothelioma cells2011

    • Author(s)
      Ghani FI, Yamazaki H, Iwata S, Okamoto T, Aoe K, Okabe K, Mimura Y, Fujimoto N, Kishimoto T, Yamada T, Xu CW, Morimoto C
    • Journal Title

      Biochem Biophys Res Commun 407

      Pages: 735-42

  • [Journal Article] High-throughput screening of glycan-binding proteins using miniature pig kidney N-glycan-immorbilized beads.2008

    • Author(s)
      Kim, Y-G, Shin, D-S, Yang, Y-H, Gil, G-C, Park, C-G, Mimura, Y, et al.
    • Journal Title

      Chem.Biol. 15

      Pages: 215-23

  • [Presentation] Impact of α1-3-linked galactose-containing oligosaccharides of mouse/human chimeric IgG on its Fc effector functions2010

    • Author(s)
      三村由香, et al.
    • Organizer
      第14回国際免疫学会発表
    • Place of Presentation
      神戸
    • Year and Date
      20100822-20100827
  • [Presentation] 糖鎖の癌性変化とサイトカインの関係2010

    • Author(s)
      三村由香、Davide Zocco、三村雄輔, 他
    • Organizer
      第20回日本サイトメトリー学会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-26
  • [Presentation] Induction of anti-tumor immunity via recycling MHC class II-guided processing2008

    • Author(s)
      三村雄輔, 他
    • Organizer
      第38回日本免疫学会総会・学術集会発表
    • Place of Presentation
      京都
    • Year and Date
      20081203-20081204
  • [Book] John Wiley & Sons2009

    • Author(s)
      Mimura, Y, Jefferis, R, Mimura-Kimura, Y, Abrahams, J, Rudd, PM
    • Total Pages
      67-89
    • Publisher
      Glycosylation of therapeutic IgGs, In Therapeutic monoclonal antibodies : From Bench to Clinic ((Ed) An, Z.)
  • [Remarks] ホームページ等

    • URL

      http://www.yamaguchi-hosp.jp/english/researchprograms/Researchprograms.html

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Published: 2012-01-26   Modified: 2016-04-21  

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