2010 Fiscal Year Final Research Report
Exploration for the factors implicated in pathogenesis and maintenance of chronic pain.
| Project/Area Number |
20602009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Aichi Medical University |
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Principal Investigator |
IWASE Satoshi Aichi Medical University, 医学部, 教授 (90184879)
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| Co-Investigator(Kenkyū-buntansha) |
OHISHI Hitoshi 愛知医科大学, 医学部, 准教授 (00252461)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Hiroki 浜松大学, 保健医療学部, 講師 (60454419)
EGUCHI Kunihiro 愛知学院大学, 歯学部, 非常勤講師 (30113062)
USHIDA Takahiro 愛知医科大学, 医学部, 教授 (60304680)
KOZAKI Yasuko 金城学院大学, 薬学部, 准教授 (20126882)
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| Research Collaborator |
YOSHIMOTO Takahiko 愛知医科大学
YAMAGUCHI Yoshiko 愛知医科大学
MORIMOTO Atsuko 愛知医科大学
OHMICHI Yusuke 愛知医科大学
OHMICHI Mika 愛知医科大学
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| Project Period (FY) |
2008 – 2010
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| Keywords | 痛み / 慢性痛 / 動物モデル / 筋障害 / 免疫・炎症 / 自律神経 / グリア |
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| Research Abstract |
In the chronic pain animal model caused by muscle insult with immuno-inflammatory and nociceptive stimuli, it was clarified that the delicate interaction between the immuno-inflammatory background and the nociceptive neural inputs may be essential to form long-persisting hypersensitivity, because pretreatment with larger-dose of immuno-inflammatory agent or treatment to immature animal prevented the development of long lasting hypersensitivity. In the cast immobilization model, it was observed that activation of spinal glial cells spread in response to spreading hypersensitivity. The sympathetic activity in this model was augmented during unilateral immobilizing, and then decreased below normal level while persisting pain behavior continued.
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Research Products
(23 results)
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[Journal Article] Frequency components of systolic blood pressure variability reflect vasomotor and cardiac sympathetic functions in conscious rats.
Author(s)
Yoshimoto T, Eguchi K, Sakurai H, Ohmichi Y, Hashimoto T, Ohmichi M, Morimoto A, Yamaguchi Y, Ushida T, Iwase S, Sugenoya J, Kumazawa T
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Journal Title
Journal of Physiological Science in press
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[Presentation] Middle and high frequency components of blood pressure variability may reflect sympathetic vasomotor and cardiac functions in conscious rats.2011
Author(s)
Yoshimoto T, Eguchi K, Sakurai H, Ohmichi Y, Hashimoto T, Ohmichi M, Morimoto A, Yamaguchi Y, Ushida T, Iwase S, Sugenoya J, Kumazawa T
Organizer
第88回日本生理学会大会(東日本大震災のため誌上開催J Physiol Sci 61(Suppl 1))
Year and Date
20110300
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[Presentation] 下肢ギプス固定がもたらす慢性的痛み行動に伴う脊髄ミクログリア・アストロサイトの変化2009
Author(s)
大道裕介, 大道美香, 大石仁, 櫻井博紀, 吉本隆彦, 森本温子, 橋本辰幸, 江口国博, 山口佳子, 中野隆, 熊澤孝朗
Organizer
第114回日本解剖学会総会・全国学術集会
Place of Presentation
岡山
Year and Date
20090300
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[Presentation] 下肢ギプス固定後に発症する慢性的痛み行動における脊髄グリア細胞の関与2008
Author(s)
大道裕介, 大道美香, 大石仁, 櫻井博紀, 吉本隆彦, 森本温子, 橋本辰幸, 江口国博, 牛田享宏, 山口佳子, 熊澤孝朗
Organizer
第23回日本整形外科学会基礎学術集会
Place of Presentation
京都
Year and Date
20081000
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