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2010 Fiscal Year Final Research Report

Activated mechanism in the neuroplasticity change of nitric oxide, which is a diagnosis and the candidate of the treatment index

Research Project

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Project/Area Number 20602012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionKansai Medical University

Principal Investigator

ABE Tetsuya  Kansai Medical University, 医学部, 講師 (20411506)

Co-Investigator(Kenkyū-buntansha) MATSUMURA Shinji  関西医科大学, 医学部, 講師 (70276393)
FUKUNAGA Mikihiko  関西医科大学, 医学部, 教授 (90257949)
Project Period (FY) 2008 – 2010
Keywords慢性疼痛 / 一酸化窒素 / 神経可塑生 / 脊髄 / 後根神経節 / グルタミン酸 / NMDA受容体
Research Abstract

Neuropathic pain produced by damage to or dysfunction of the nervous system is a common and severely disabling state that affects million of people worldwide. Fyn kinase-mediated phosphorylation of NR2B subunits of NMDA receptors at Tyr1472 in the dorsal horn may have dual roles in the retention of NMDA receptors in the postsynaptic density and in activation of nitric oxide synthase. Y1472F-KI mice witha knock-in mutation of the Tyr1472 site to phenylalanine did not exhibit neuropathic pain induced by L5 spinal nerve transection.

  • Research Products

    (11 results)

All 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury.2010

    • Author(s)
      Matsumura S, Takagi K, Okuda-Ashitaka E, Lu J, Naritsuka H, Yamaguchi M, Ito S
    • Journal Title

      Neuroscience 170

      Pages: 921-953

    • Peer Reviewed
  • [Journal Article] Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472.2010

    • Author(s)
      Matsumura S, Kunori S, Mabuchi T, Katano T, Nakazawa T, 阿部哲也, Watanabe M, Yamamoto T, Okuda-Ashitaka E, Ito S
    • Journal Title

      Eur.J.Neurosci. 32

      Pages: 798-810

    • Peer Reviewed
  • [Journal Article] A novel role of prostaglandin E2 in neuropathic pain : blockade of microglial migration in the spinal cord.2010

    • Author(s)
      Kunori S, Matsumura S, Okuda-Ashitaka E, Katano T, Audoly LP, Urade Y, Ito S
    • Journal Title

      Glia 59

      Pages: 208-209

    • Peer Reviewed
  • [Journal Article] Translocation of neuronal nitric oxide synthase to the plasma membrane by ATP is mediated by P2X and P2Y receptors.2009

    • Author(s)
      Ohnishi T, Matsumura S, Ito S
    • Journal Title

      Molecular Pain 5

      Pages: 40_1-40_16

    • Peer Reviewed
  • [Journal Article] Involvement of prostaglandin F 2 alpha receptor in ATP-induced mechanical allodynia.2009

    • Author(s)
      Kunori S, Matsumura S, Mabuchi T, Tatsumi S, Sugimoto Y, Minami T, Ito S
    • Journal Title

      Neuroscience 163

      Pages: 362-371

    • Peer Reviewed
  • [Journal Article] Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation.2008

    • Author(s)
      Takagi K, Okuda-Ashitaka E, Mabuchi T, Katano T, Ohnishi T, Matsumura S, Ohnaka M, Kaneko S, Abe, T, Hirata T, Fujiwara S, Minami T, Ito S
    • Journal Title

      Neuroscience 153

      Pages: 1278-1288

    • Peer Reviewed
  • [Journal Article] Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP.2008

    • Author(s)
      Ohnishi T, Okuda-Ashitaka E, Matsumura S, Katano T, Nishizawa M, Ito S
    • Journal Title

      J.Neurochem. 105

      Pages: 2271-2285

    • Peer Reviewed
  • [Journal Article] 痛みにおけるNOの関与2008

    • Author(s)
      松村伸治、阿部哲也、芦高恵美子、伊藤誠二
    • Journal Title

      Bio Clinica 第23巻第5号

      Pages: 19-25

  • [Presentation] Attenuation of neuropathic pain by impaired Ca2+ signaling in mutant mice lacking the Tyr-1472 phosphorylation site of the NR2B2010

    • Author(s)
      Matsumura S, Kunori S, Nakazawa T, Abe T, Yamamoto T, Katano T, Watanabe M, Okuda-Ashitaka E, Ito S
    • Organizer
      Sciety for Neuroscience
    • Place of Presentation
      Sandiego, 米国
    • Year and Date
      2010-11-15
  • [Remarks] ホームページ等

    • URL

      http://image.tnoc.kmu.ac.jp/bmrc/

  • [Patent(Industrial Property Rights)] 埋植用鎮痛製剤2010

    • Inventor(s)
      荒木吉朗、海堀昌樹、松村伸治、伊藤誠二、權雅憲
    • Industrial Property Rights Holder
      学校法人関西医科大学
    • Industrial Property Number
      特許,特願2010-127252
    • Filing Date
      2010-06-02

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Published: 2012-01-26   Modified: 2016-04-21  

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