2010 Fiscal Year Final Research Report
The role of GIRK channel gene polymorphisms in the individual differences in sensitivity to analgesics
Project/Area Number |
20602020
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
疼痛学
|
Research Institution | Tokyo Metropolitan Organization for Medical Research |
Principal Investigator |
NISHIZAWA DAISUKE Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 流動研究員 (80450584)
|
Co-Investigator(Kenkyū-buntansha) |
IKEDA Kazutaka 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 副参事研究員 (60281656)
|
Project Period (FY) |
2008 – 2010
|
Keywords | 鎮痛薬感受性個人差 / GIRKチャネル / 遺伝子多型 / 薬理遺伝学 / 個別化医療 / 関連研究 |
Research Abstract |
In association studies targeting genetic polymorphisms identified in brain-type GIRK1-GIRK3 genes, significant associations were found between the GIRK3 C1339T, C1781T and C1817T polymorphisms and requirements of postoperative 24-h opioid analgesics after major open abdominal surgery or painful orofacial cosmetic surgery. In particular, there were significant associations in the C1781T and C1817T between analgesic requirements and mRNA expressions, suggesting that the GIRK3 mRNA expression could affect the analgesic effects of opioids.
|
-
-
[Journal Article] Association between KCNJ6 ( GIRK2) Gene polymorphisms and postoperative analgesic requirements after major abdominal surgery2009
Author(s)
Nishizawa D, Nagashima M, Katoh R, Satoh Y, Tagami M, Kasai S, Ogai Y, Han W, Hasegawa J, Shimoyama N, Sora I, Hayashida M, Ikeda K
-
Journal Title
Peer Reviewed
-
-
[Presentation] Association between GIRK3 gene polymorphisms and postoperative analgesic requirements after major abdominal surgery2010
Author(s)
Nishizawa D, Nagashima M, Kato R, Sato Y, Tagami M, Kasai S, Ogai Y, Hasegawa J, Hayashida M, Ikeda K
Organizer
The American Society of Human Genetics 60th Annual Meeting
Place of Presentation
Washington DC, USA
Year and Date
2010-11-03
-
-
-
-
[Presentation] GIRKチャネル遺伝子GIRK2の遺伝子多型と開腹術後鎮痛との関連2009
Author(s)
Nishizawa D, Nagashima M, Katoh R, Satoh Y, Tagami M, Kasai S, Ogai Y, Han W, Hasegawa J, Shimoyama N, Sora I, Hayashida M, Ikeda K
Organizer
第39回日本神経精神薬理学会
Place of Presentation
京都
Year and Date
2009-11-14
-
-
-
-
-