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2010 Fiscal Year Final Research Report

The role of GIRK channel gene polymorphisms in the individual differences in sensitivity to analgesics

Research Project

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Project/Area Number 20602020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

NISHIZAWA DAISUKE  Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 流動研究員 (80450584)

Co-Investigator(Kenkyū-buntansha) IKEDA Kazutaka  財団法人東京都医学研究機構, 東京都精神医学総合研究所, 副参事研究員 (60281656)
Project Period (FY) 2008 – 2010
Keywords鎮痛薬感受性個人差 / GIRKチャネル / 遺伝子多型 / 薬理遺伝学 / 個別化医療 / 関連研究
Research Abstract

In association studies targeting genetic polymorphisms identified in brain-type GIRK1-GIRK3 genes, significant associations were found between the GIRK3 C1339T, C1781T and C1817T polymorphisms and requirements of postoperative 24-h opioid analgesics after major open abdominal surgery or painful orofacial cosmetic surgery. In particular, there were significant associations in the C1781T and C1817T between analgesic requirements and mRNA expressions, suggesting that the GIRK3 mRNA expression could affect the analgesic effects of opioids.

  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Book (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 4 results)

  • [Journal Article] Identification of Selective Agonists and Antagonists to Gn Protein-Activated Inwardly Rectifying Potassium Channels: Potassium Channels : Candidate Medicines for Drug Dependence and Pain2011

    • Author(s)
      Nishizawa D, Gajya N, Ikeda K
    • Journal Title

      Current Neuropharmacology Vol.9

      Pages: 113-117

  • [Journal Article] Association between KCNJ6 ( GIRK2) Gene polymorphisms and postoperative analgesic requirements after major abdominal surgery2009

    • Author(s)
      Nishizawa D, Nagashima M, Katoh R, Satoh Y, Tagami M, Kasai S, Ogai Y, Han W, Hasegawa J, Shimoyama N, Sora I, Hayashida M, Ikeda K
    • Journal Title

      PLoS ONE 4巻

      Pages: e7060

    • Peer Reviewed
  • [Journal Article] 遺伝子多型と疼痛感受性,オピオイド感受性-基礎および臨床のデータから-2009

    • Author(s)
      西澤大輔,長島誠,佐藤泰雄,田上惠,池田和隆
    • Journal Title

      麻酔 58巻

      Pages: 1093-1101

    • Peer Reviewed
  • [Presentation] Association between GIRK3 gene polymorphisms and postoperative analgesic requirements after major abdominal surgery2010

    • Author(s)
      Nishizawa D, Nagashima M, Kato R, Sato Y, Tagami M, Kasai S, Ogai Y, Hasegawa J, Hayashida M, Ikeda K
    • Organizer
      The American Society of Human Genetics 60th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-11-03
  • [Presentation] 遺伝子解析による術後疼痛、がん性疼痛マネジメントへの貢献2010

    • Author(s)
      西澤大輔,池田和隆
    • Organizer
      第4回日本緩和医療薬学会年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-09-25
  • [Presentation] GIRKチャネルサブユニットGIRK3の遺伝子多型と開腹術後鎮痛との関連2010

    • Author(s)
      西澤大輔,長島誠,加藤良二,佐藤泰雄,田上惠,笠井慎也,大谷保和,長谷川準子,林田眞和,池田和隆
    • Organizer
      第40回日本神経精神薬理学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-17
  • [Presentation] Polymorphisms of the genes encoding the mu-opioid receptor and GIRK2 ( KCNJ6) are associated with postoperative opioid requirements2010

    • Author(s)
      Ikeda K, Nishizawa D, Kasai S, Fukuda K, Hayashida M
    • Organizer
      CINP 2010
    • Place of Presentation
      Hong kong
    • Year and Date
      2010-06-08
  • [Presentation] GIRKチャネル遺伝子GIRK2の遺伝子多型と開腹術後鎮痛との関連2009

    • Author(s)
      Nishizawa D, Nagashima M, Katoh R, Satoh Y, Tagami M, Kasai S, Ogai Y, Han W, Hasegawa J, Shimoyama N, Sora I, Hayashida M, Ikeda K
    • Organizer
      第39回日本神経精神薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-14
  • [Book] Methods in Molecular Biology(Genetic polymorphisms and human sensitivity to opioid analgesics)2010

    • Author(s)
      Nishizawa D, Hayashida M, Nagashima M, Koga H, Ikeda K
    • Total Pages
      395-420
    • Publisher
      Totowa : The humana press Inc.
  • [Patent(Industrial Property Rights)] Method of evaluating drug-sensitivity by analyzing the GIRK channel genes2010

    • Inventor(s)
      Ikeda K, Hayashida M, 西澤大輔,Sora I
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構
    • Industrial Property Number
      特許,Britain Part of the European Patent Office, EP(UK)No.1895016
    • Filing Date
      2010-09-06
    • Overseas
  • [Patent(Industrial Property Rights)] Method of evaluating drug-sensitivity by analyzing the GIRK channel genes2010

    • Inventor(s)
      Ikeda K, Hayashida M, 西澤大輔,Sora I
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構
    • Industrial Property Number
      特許,German Part of the European Patent Office, 602007007697.8-08
    • Filing Date
      2010-07-28
    • Overseas
  • [Patent(Industrial Property Rights)] Method of evaluating drug-sensitivity by analyzing the GIRK channel genes2010

    • Inventor(s)
      Ikeda K, Hayashida M, 西澤大輔,Sora I
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構
    • Industrial Property Number
      特許,France Part of the European Patent Office, E1895016
    • Filing Date
      2010-07-17
    • Overseas
  • [Patent(Industrial Property Rights)] Method of evaluating drug-sensitivity by analyzing the GIRK channel genes2010

    • Inventor(s)
      Ikeda K, Hayashida M, 西澤大輔,Sora I
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構
    • Industrial Property Number
      特許,European Patent Office, 1895016
    • Filing Date
      2010-07-14
    • Overseas

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Published: 2012-01-26   Modified: 2016-04-21  

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