Establishment of iPS cell transplantation that does not form teratomas

2010 Fiscal Year Final Research Report

• Project/Area Number: 20610006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Stem cell biology and medical science
• Research Institution: Keio University
• Principal Investigator: AKAMATSU Wado Keio University, 医学部, 講師 (60338184)
• Project Period (FY): 2008 – 2010
• Keywords: iPS細胞 / 神経幹細胞

Research Abstract

We have succeeded in generating neural stem cells from mouse fibroblasts by using gene transfer. These neural stem cells are mature and contain few residual pluripotent cells.

Research Products

• [Journal Article] Generation of human melanocytes from induced pluripotent stem cells. (2011)
  • Author(s): Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y.
  • Journal Title: PLoS One. 6(1) Pages: e16182
  • Peer Reviewed
• [Journal Article] Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. (2009)
  • Author(s): Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D.
  • Journal Title: J Neurosci. 29(7) Pages: 2113-24
  • Peer Reviewed
• [Presentation] Generation of human iPS-derived melanocytes in vitro (2009)
  • Author(s): Shigeki Ohta, Wado Akamatsu, Yohei Okada, Yumi Matsuzaki, Hideyuki Okano, Yutaka Kawakami
  • Organizer: 2009年度日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-20091212
• [Presentation] 孤発性筋萎縮性側索側策硬化症患者からのiPS細胞樹立 (2009)
  • Author(s): 二瓶義廣
  • Organizer: 第28回日本認知症学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 20091120-20091122
• [Presentation] Molecular profiling of schizophrenia by use of patient-derived olfactory neurons and induced pluripotent stem (iPS) cells (2009)
  • Author(s): S.-I. KANO
  • Organizer: 北米神経科学会年会2009
  • Place of Presentation: シカゴ
  • Year and Date: 20091017-20091021
• [Presentation] RETROVIRUS/LENTIVIRUS INTEGRATION SITE ANALYSIS OF HUMAN INDUCED PLURIPOTENT STEM (iPS) CELLS (2009)
  • Author(s): Yoshikazu Sugimoto
  • Organizer: 第15回日本遺伝子治療学会
  • Place of Presentation: 大阪
  • Year and Date: 20090707-20090709
• [Presentation] 岡野栄之再生医療の現状と将来の見通し (2009)
  • Author(s): 赤松和土
  • Organizer: 第35回BMSコンファレンス基調講演
  • Place of Presentation: 高知
  • Year and Date: 20090705-20090707
• [Presentation] 孤発性パーキンソン病患者からのiPS細胞の樹立 (2009)
  • Author(s): 八木拓也
  • Organizer: 第50回日本神経学会
  • Place of Presentation: 仙台
  • Year and Date: 20090520-20090522
• [Presentation] GCNF/Oct4シグナルによる初期神経幹細胞の分化誘導と万能性の抑制 (2008)
  • Author(s): 赤松和土, DeVeale B,岡野栄之,Cooney AJ, van der Kooy D
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 20080709-20090711