2010 Fiscal Year Final Research Report
Development of specific probes for auxin receptors, TIR1 and ABP1, and Study for auxin signaling.
| Project/Area Number |
20611019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Okayama University of Science |
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Principal Investigator |
HAYASHI Ken-Ichiro Okayama University of Science, 理学部, 准教授 (30289136)
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| Co-Investigator(Renkei-kenkyūsha) |
NOZAKI Hiroshi 岡山理科大学, 理学部, 教授 (60159085)
STEFAN Kepinski University of Leeds, Center for Plant Sciences, Ph.D.
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| Project Period (FY) |
2008 – 2010
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| Keywords | オーキシン / 分子プローブ / TIR1受容体 / 阻害剤 / 植物ホルモン |
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| Research Abstract |
Auxin palys a crucial role in plant development. Auxin is perceived by two types of receptors, TIR1 nuclear receptor and ABP1 membrane receptor. These two auxin receptors regulate various auxin responses in plant. Small molecule probes specific for TIR1 and ABP1 were developed to investigate the physiological function of TIR1 and ABP1 receptors in auxin signaling. As the results, small molecule probes were designed to show specific effects for each auxin receptor.
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[Journal Article] Alkoxy-auxins are selective inhibitors of auxin transport mediated by PIN, ABCB, and AUX1 transporters.2011
Author(s)
E.Tsuda, H.Yang, T.Nishimura, Y.Uehara,T.Sakai, M.Furutani, T.Koshiba, M.Hirose, H.Nozaki, AS.Murphy, K.Hayashi
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Journal Title
J Biol Chem. 286
Pages: 2354-64
Peer Reviewed
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[Journal Article] ABP1 Mediates auxin inhibition of clathrin-dependent Endocytosis in Arabidopsis.2010
Author(s)
S.Robert, J.Kleine-Vehn, E.Barbez, M.Sauer, T.Paciorek, P.Baster,S.Vanneste, J.Zhang, S.Simon, M.Covanova, K.Hayashi, P.Dhonukshe, Z.Yang, S.Y.Bednarek, A.M.Jones, C.Luschnig, F.Aniento, E.Zazimalova, J.Friml
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Journal Title
Peer Reviewed
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[Journal Article] Endogenous diterpenes derived from ent-kaurene, a common gibberellin precursor, regulate protonema differentiation of the moss Physcomitrella patens.2010
Author(s)
K.Hayashi, K.Horie, Y.Hiwatashi, H.Kawaide, S.Yamaguchi, A.Hanada, T.Nakashima, M.Nakajima, L.N.Mander, H.Yamane, M.Hasebe, H.Nozaki
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Journal Title
Plant Physiol. 153
Pages: 1085-97
Peer Reviewed
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