2010 Fiscal Year Final Research Report
Development of the photochemical panning adapted to low affinity ligands and analysis of neural carbohydrates' functions
Project/Area Number |
20611021
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical biology
|
Research Institution | Kyushu University of Health and Welfare |
Principal Investigator |
SADAKANE Yutaka Kyushu University of Health and Welfare, 薬学部, 准教授 (60293304)
|
Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Masahiro 九州保健福祉大学, 薬学部, 教授 (40224828)
KONOHA Keiko 九州保健福祉大学, 薬学部, 助手 (00369175)
OHTSUKA Isao 九州保健福祉大学, 薬学部, 講師 (20389589)
|
Co-Investigator(Renkei-kenkyūsha) |
OHTSUKA Isao 九州保健福祉大学, 薬学部, 講師 (20389589)
|
Project Period (FY) |
2008 – 2010
|
Keywords | 光反応 / アミロイド / プロテオーム / 神経科学 / 糖鎖 / 薬学 / 分析化学 / バイオテクノロジー |
Research Abstract |
We established the synthetic methods for photo-reactive carbohydrates, in which carbohydrate reducing end was cyclic form, i.e. natural form. Experiments using the new photo-reactive lactose ligand revealed that cyclic form of lactose showed high affinity and high specificity comparing acyclic form of lactose. We also analyzed the interaction between carbohydrates and Alzheimer's beta-amyloid peptides on the lipid membrane by atomic force microscope, and revealed that the interaction of ganglioside and amyloid peptide generated the specific aggregation on lipid layer.
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Research Products
(35 results)