2010 Fiscal Year Final Research Report
Development of targeting method of subcellular organelles using focusing heavy-ion microbeam.
| Project/Area Number |
20612013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Quantum beam science
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
FUNAYAMA Tomoo Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究主幹 (40354956)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 低線量放射線影響 / 重イオン / マイクロビーム |
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| Research Abstract |
To elucidate mechanisms underlying biological responses of heavy-ion irradiated cells, a targeting method of subcellular regions using focusing heavy-ion microbeam was developed. An installation of a cell targeting system, an establishment of protocol for preparing target sample, and a development of an image analysis code that can extract cell coordinates from fluorescent-dye-stained cell image were carried out. The developed system was able to target and irradiate individual cultured cells using focusing heavy-ion microbeam.
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