2010 Fiscal Year Final Research Report
Structure determination method for non-crystallizable proteins by synchrotron radiation hard X-rays
| Project/Area Number |
20612022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Quantum beam science
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| Research Institution | Japan Synchrotron Radiation Research Institute |
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Principal Investigator |
IWAMOTO Hiroyuki Japan Synchrotron Radiation Research Institute, 主幹研究員 (60176568)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 量子ビーム / 放射光硬X線 / 結晶化困難タンパク質 / 流動配向法 / X線ホログラフィー |
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| Research Abstract |
About 70% of currently used medical drugs are said to be targeted to membrane proteins. Because of this, the knowledge about the 3D structure of these proteins is indispensable for the development of new drugs. However, the structures of only a few of the membrane proteins have been solved, because it is generally difficult to obtain crystals of these proteins, which are indispensable for the standard procedure of structure determination. This study is conducted to develop the principles needed to determine the structure of these proteins without making crystals, by applying the technique of X-ray holography.
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