2012 Fiscal Year Final Research Report
Multidimensional omics analyses of brain anatomy
| Project/Area Number |
20670004
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| Research Category |
Grant-in-Aid for Young Scientists (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2012
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| Keywords | リピドーム / メタボローム / オミックス / 質量顕微鏡 |
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| Research Abstract |
Using imaging mass spectrometry we developed, we analyzednervous system in animal models and postmortem human brains. We revealed very unique region-specific or cell type-specific localization of lipids, peptides, and low-molecular metabolites. Furthermore, we offered some candidates for new disease markers by analyzing the human diseased brain. Using animal models, to analyze the time course of brain diseases, we identified spatiotemporal changes of low molecular weight metabolites and lipids. We achieved the multidimensional omics analyses of brain anatomy.
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[Journal Article] Abnormal phospholipids distribution in theprefrontal cortex from a patient withschizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry2011
Author(s)
Matsumoto J, Sugiura Y, Yuki D, Hayasaka T, Goto-Inoue N,Zaima N, Kunii Y, Wada A, Yang Q, Nishiura K, Akatsu H, Hori A, Hashizume Y, Yamamoto T, Ikemoto K, Setou M, Niwa SI
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Journal Title
Anal Bioanal Chem
Volume: 400巻
Pages: 1933-43
DOI
Peer Reviewed
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