2013 Fiscal Year Final Research Report
Design, Synthesis and Biological Application of Chemical Probes for in vivo Imaging
| Project/Area Number |
20675004
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| Research Category |
Grant-in-Aid for Young Scientists (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Osaka University |
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Principal Investigator |
KIKUCHI Kazuya 大阪大学, 大学院・工学研究科, 教授 (70292951)
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| Project Period (FY) |
2008 – 2013
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| Keywords | 生物無機化学 / 可視化プローブ |
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| Research Abstract |
One of the great challenges in the post-genome era is to clarify the biological significance of intracellular molecules directly in living cells. If we can visualize a molecule in vivo, it is possible to acquire biological information, which is unavailable if we deal with cell homogenates. One possible approach is to design and synthesize chemical probes that can convert biological information to chemical output. Novel MRI probes with tunable switches and novel methods to label target proteins with functional molecules are developed.
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[Remarks] (1) 第31回(2013年度)大阪科学賞受賞2013年11月
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[Remarks] (2) 第29回(2012年度)井上学術賞受賞2013年2月
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[Remarks] (3) 第29回(平成23年度)日本化学会学術賞受賞2012年3月
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[Remarks] (4) 第6回(平成21年度)日本学術振興会賞受賞2010年3月
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[Remarks] (5) Royal Society of Chemistry(英国王立化学会)Emerging Investigator Award 受賞 2008年12月
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[Remarks] (6) 第22回日本IBM科学賞受賞 2008年11月
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