2010 Fiscal Year Final Research Report
D-amino acids and beta-amino acids : a new frontier in Ribosomal synthesis of non-standard polypeptides
| Project/Area Number |
20681022
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MURAKAMI Hiroshi The University of Tokyo, 大学院・総合文化研究科, 准教授 (10361669)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生合成 / 翻訳合成 / D体アミノ酸 / ベータアミノ酸 / 非蛋白質性アミノ酸 |
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| Research Abstract |
It is believed that the ribosomal translation machinery does not accept D-amino acids and beta-amino acids. In this study, we investigated the incorporation of these non-proteinogenic amino acids into peptides, and found that the translation machinery actually accepts several kinds of D-amino acids as well as beta-amino acids. These results open the way for the ribosomal synthesis of novel non-standard peptides with main-chain modified groups, and would facilitate the use of these unique building blocks in peptides for drug discovery.
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