2010 Fiscal Year Final Research Report
Studies on the Transition Metal-Rare Earth Metal/Dinuclear Schiff Base Catalysts, Mechanistic Studies and Application to New Asymmetric Reactions
| Project/Area Number |
20685008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | 触媒 / 不斉合成 / 不斉触媒 / サレン / 非天然アミノ酸 / 医薬品合成 |
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| Research Abstract |
Characterization of hetero-dinuclear rare earth metal/transition metal Schiff base complexes, as well as their applications to various enantioselective reactions have been investigated. Catalytic asymmetric nitro-Mannich-type reactions, catalytic asymmetric α-addition of isocyanato esters to aldehydes, and so on have been successfully developed, leading to providing useful synthetic methods for chiral nitrogen-containing building blocks. Thus, the achievement can contribute for the efficient synthesis of pharmaceuticals.
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