2010 Fiscal Year Final Research Report
Neuromolecular and behavioral studies for management of developmental animals.
| Project/Area Number |
20688012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Azabu University |
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Principal Investigator |
KIKUSUI Takefumi Azabu University, 獣医学部, 教授 (90302596)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 早期離乳 / BDNF / コルチコステロン / メチル化 |
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| Research Abstract |
Disruption of the mother-pup interaction changes the physiology and behavior of pups via epigenetic modifications.We have demonstrated that early weaning results in a persistent increase in anxiety-like and aggressive behavior in adult mice. Early-weaned mice also showed higher hypothalamic-pituitary-adrenal activity in response to novelty stress. Neurochemically, early-weaned male mice, but not female mice, showed precocious myelination in the amygdala, decreased brain-derived neurotrophic factor protein levels in the hippocampus and prefrontal cortex, and reduced bromodeoxyuridine immunoreactivity in the dentate gyrus. The early weaned mice showed higher corticosterone response more than 48 hours, and this increment of corticosterone caused many aspects of early-weaning phenomena. Thus higher glucocorticoid secretion in the developmental period has a great impact on brain development.
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[Journal Article] A male mouse pheromone ESP1 enhances female sexual receptive behavior via a select vomeronasal receptor.2010
Author(s)
Haga, S., Hattori, T., Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K.
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Journal Title
Nature 466
Pages: 118-122
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[Journal Article] Abnormalities in Aggression and Anxiety in Transgenic Mice Overexpressing Activin E.2009
Author(s)
Sekiyama, T., Ushiro, U., Adachi, C., Kikusui, T., Tanemura, K., Hasegawa, Y.
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Journal Title
Biochemical and Biophysical Research Communications. 385(3)
Pages: 319-323
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[Journal Article] Physiol.Behav.2009
Author(s)
Inagaki, H., Nakamura, K., Kiyokawa, Y., Kikusui, T., Takeuchi, Y., Mori, Y.
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Journal Title
The volatility of an alarm pheromone in male rats. 96
Pages: 749-752
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[Presentation] A MALE PEPTIDE PHEROMONE ESP1 ENHANCES FEMALE LORDOSIS BEHAVIOR IN MICE2010
Author(s)
Kikusui T, Haga, S., Hattori, T., Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Touhara K.
Organizer
Society for Behavioral Neuroendocrinology
Place of Presentation
Toronto
Year and Date
20100720-20100722
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[Presentation] The mouse peptide pheromone ESP1 enhances female sexual receptive behavior via a specific vomeronasal receptor.2009
Author(s)
Haga, S., Hattori, T., Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K.
Organizer
第32回分子生物学会
Place of Presentation
パシフィコ横浜
Year and Date
20091209-20091212
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[Presentation] Janelia conference "Neural Circuits Controlling Sexual Behavior" The peptide pheromone ESP1 activates a selective vomeronasal neural circuitry mediating sexual behavior in female mice.2009
Author(s)
Haga, S., Hattori, T., Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K.
Organizer
Howard Hughes Medical Institute Janelia Farm Research Campus
Year and Date
20091011-20091014
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[Presentation] Keystone metting "Chemical Senses : Receptors and Circuits" Vomeronasal receptor-mediated neural circuitry and behavior activated by a male-specific peptide pheromone ESP12009
Author(s)
Haga, S., Hattori, T., Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K.
Organizer
Granlibakken Resort
Place of Presentation
Tahoe City, California
Year and Date
20090315-20090319
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