2010 Fiscal Year Final Research Report
Mechanisms of hemolysis caused by anti-erythrocyte antibodies in the pathological condition of canine babesiosis.
| Project/Area Number |
20688014
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMASAKI Masahiro Hokkaido University, 大学院・獣医学研究科, 准教授 (40322846)
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| Project Period (FY) |
2008 – 2010
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| Keywords | イヌバベシア症 / 抗赤血球抗体 / heat shock protein 70 / バベシア原虫 / 貧血 |
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| Research Abstract |
In canine babesiosis, antibodies that reacted with canine heat shock protein 70 (hsp70) were detected in dog sera. Because hsp70 from Babesia parasites showed high homology with canine hsp70, anti-Babesia parasite hsp70 antibody might cross-react with canine hsp70. Since canine hsp70 was expressed in canine erythrocytes, it was possible that anti-hsp70 antibodies in dog sera would be anti-erythrocyte membrane antibodeis ; however, canine hsp70 was not found on the membrane surface of erythrocytes, suggesting that erythrocytes would not be targets of anti-hsp70 antibody.
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[Journal Article] Detection in blood smears and formalin-fixed, paraffin-embedded tissues using deoxyribonucleic acid in situ hybridization analysis.2011
Author(s)
Masahiro Yamasaki, Yusuke Kobayashi, Kensuke Nakamura, Noboru Sasaki, Masahiro Murakami, Wickramasekara Rajapakshage Bandula Kumara, Hiroshi Ohta, Osamu Yamato, Yoshimitsu Maede, Mitsuyoshi Takiguchi, Babesia gibsoni
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Journal Title
Experimental Parasitoloty 127巻
Pages: 119-126
Peer Reviewed
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[Journal Article] Evaluation of efficary of Bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis.2009
Author(s)
Ryo Nakao, Chiaki Mizukami, Yuta Kawamura, Subeki, Saw Bawm, Masahiro Yamasaki, Yoshimitsu Maede, Hideyuki Matsuura, Kensuke Nabeta, Nariaki Nonaka, Yuzaburo Oku, Ken Katakura
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Journal Title
Journal of Veterinary Medical Science 71巻
Pages: 33-41
Peer Reviewed
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