2009 Fiscal Year Final Research Report
Development of diagnostic imaging reagents based on designing and synthesizing fluorescent probes
| Project/Area Number |
20689003
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOJIMA Hirotatsu The University of Tokyo, 生物機能制御化合物ライブラリー機構, 准教授 (70345255)
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| Project Period (FY) |
2008 – 2009
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| Keywords | イメージング / 画像化 / 蛍光 / 近赤外 |
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| Research Abstract |
Reactive oxygen species (ROS) operate as signaling molecules undervarious physiological conditions, and overproduction of ROS is involved in the pathogenesisof many diseases. Therefore, fluorescent probes for visualizing ROS are promising toolswith which to uncover the molecular mechanisms of physiological and pathologicalprocesses and might also be useful for diagnosis. We developed such a novel fluorescenceprobe, operating in the physiologically favorable near-infrared region.
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[Journal Article] Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes.2010
Author(s)
Oushiki, D., Kojima, H., Terai, T., Arita, M., Hanaoka, K., Urano, Y., Nagano, T.
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Journal Title
J. Am. Chem. Soc. 132
Pages: 2795-2801
Peer Reviewed
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[Journal Article] Molecular design strategies for near-infrared ratiometric fluorescent probes based on unique spectral properties of aminocyanines.2009
Author(s)
Kiyose, K., Aizawa, S., Sasaki, E., Kojima, H., Hanaoka, K., Terai, T., Urano, Y., Nagano, T.
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Journal Title
Chem. Eur. J. 15
Pages: 9191-9200
Peer Reviewed
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[Journal Article] Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase (GST) and application for activity imaging in living cells.2008
Author(s)
Fujikawa, Y., Urano, Y., Komatsu, T., Hanaoka, K., Kojima, H., Terai, T., Inoue, H., Nagano, T.
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Journal Title
J. Am. Chem. Soc. 130
Pages: 14533-14543
Peer Reviewed
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