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2009 Fiscal Year Final Research Report

Immunoprofiling of signaling molecule on malignant tumor

Research Project

  • PDF
Project/Area Number 20689010
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionHokkaido University

Principal Investigator

NISHIHARA Hiroshi  Hokkaido University, 大学院・医学研究科, 特任准教授 (50322805)

Project Period (FY) 2008 – 2009
Keywords診断病理学
Research Abstract

The development of molecular targeted therapy for cancer treatment is necessary to establish the "Taylor made medicine", and also requires the personalized diagnostic system to evaluate the individual biological malignancy. In this study, we have performed the immunostain on the human cancer specimens for multiple signaling molecules, such as receptor tyrosine kinases and adaptor proteins, to establish the pathological basis for the personalized pathological diagnosis.

  • Research Products

    (14 results)

All 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] DOCK2 regulates cell proliferation through Rac and ERK activation in B cell lymphoma.2010

    • Author(s)
      Wang L, Nishihara H, Kimura T, Kato Y, Tanino M, Nishio M, Obara M, Endo T, Koike T, Tanaka S
    • Journal Title

      Biochem Biophys Res Commun (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks.2010

    • Author(s)
      Tabu K, Kimura T, Sasai K, Wang L, Bizen N, Nishihara H, Taga T, Tanaka S
    • Journal Title

      Mol Cancer 9(1)

      Pages: 39

    • Peer Reviewed
  • [Journal Article] Sudden death of a patient with pandemic influenza (A/H1N1pdm) virus infection by acute respiratory distress syndrome.2010

    • Author(s)
      Takiyama A, Wang L, Tanino M, Kimura T, Kawagishi N, Kunieda Y, Katano H, Nakajima N, Hasegawa H, Takagi T, Nishihara H, Sata T, Tanaka S
    • Journal Title

      Jpn J Infect Dis 63(1)

      Pages: 72-4

    • Peer Reviewed
  • [Journal Article] A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings.2009

    • Author(s)
      Nishihara H, Nakasato M, Sawa H, Murakami H, Yamamoto D, Moriyama K, Kato N, Hashimoto I, Kamada H, Tanaka S
    • Journal Title

      J Neurooncol 93(2)

      Pages: 275-8

  • [Journal Article] Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration.2009

    • Author(s)
      Kimura T, Sakai M, Tabu K, Wang L, Tsunematsu R, Tsuda M, Sawa H, Nagashima K, Nishihara H, Hatakeyama S, Nakayama K, Ladanyi M, Tanaka S, Nakayama KI
    • Journal Title

      Lab Invest 89(6)

      Pages: 645-56

    • Peer Reviewed
  • [Journal Article] Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.2009

    • Author(s)
      Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S
    • Journal Title

      Cell Res. 19(5)

      Pages: 638-50

    • Peer Reviewed
  • [Presentation] Clinicopathological analysis for glioma-specific vascular structures.2009

    • Author(s)
      Hiroshi Nishihara, Mitsunobu R. Kano, Hiromi Kanno, Shinya Tanaka
    • Organizer
      AACR Special Conference on Genetics and Biology of Brain Cancers
    • Place of Presentation
      アメリカ、サンディエゴ
    • Year and Date
      20091213-20091215
  • [Presentation] CNS-lymphomatoid granulomatosis; as a primary lesion for CNS-T cell lymphoma2009

    • Author(s)
      Hiroshi Nishihara, Kazuo Nagashima, Shinya Tanaka
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20091001-20091003
  • [Presentation] MDS患者のリンパ節に発生したtrilineage extramedullary myeloid cell tumorの1例2009

    • Author(s)
      西原広史、高阪真路、久保田佳奈子、田中伸哉、松野吉宏
    • Organizer
      第49回日本リンパ網内系学会総会
    • Place of Presentation
      淡路島
    • Year and Date
      20090709-20090711
  • [Presentation] 髄膜腫におけるDOCK180の発現の検討2009

    • Author(s)
      西原広史、村上普美、木村憲一、佐和弘基、鎌田一、田中伸哉
    • Organizer
      第50回日本神経病理学会学術研究会
    • Place of Presentation
      香川
    • Year and Date
      20090606-20090608
  • [Presentation] 脳腫瘍血管壁の組織病理学的解析:Glomeruloid vesselは肥厚した幼若なPericyteで構成されている2009

    • Author(s)
      西原広史、狩野光伸、田中伸哉
    • Organizer
      第27回日本脳腫瘍病理学会総会
    • Place of Presentation
      福岡
    • Year and Date
      20090508-20090509
  • [Presentation] Pathological analysis for cancer-mesenchymal and vascular structure associated with drug delivery system.2009

    • Author(s)
      西原広史
    • Organizer
      第25回日本DDS学会学術集会ワークショップDDSとがん組織(間質、脈管)
    • Place of Presentation
      東京
    • Year and Date
      20090000
  • [Presentation] Pilomyxoid patternを示すAnaplastic oligoastrocytoma (AOA)の病理学的検討2008

    • Author(s)
      西原広史、長嶋和郎、田中伸哉
    • Organizer
      第26回日本脳腫瘍病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      20080523-20080524
  • [Presentation] Paul A. Insel. Cyclic AMP-dependent regulation of colon cancer growth and apoptosis: A key role for COX-22008

    • Author(s)
      Hiroshi Nishihara, Hiroshi Yokouchi, Shinya Tanaka, Lars Eckmann
    • Organizer
      AACR (American Society of Cancer Research)
    • Place of Presentation
      アメリカ、サンディエゴ
    • Year and Date
      20080000

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Published: 2011-06-18   Modified: 2016-04-21  

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