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2010 Fiscal Year Self-evaluation Report

Elucidating pathomechanism for bullous pemphigoid by molecular imaging of collagen XVII.

Research Project

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Project/Area Number 20689021
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

NISHIE Wataru  Hokkaido University, 大学病院, 講師 (20443955)

Project Period (FY) 2008 – 2011
Keywords生体分子 / 細胞・組織 / タンパク質 / 酵素 / 応用動物
Research Abstract

本研究の目的は、自己免疫性水疱症の中で最も患者数の多い水疱性類天疱瘡(bullous pemphigoid ; BP)の病態メカニズムを解明する事である。その手法として、BPの自己抗原であり表皮基底細胞ヘミデスモゾーム構成分子の1つのXVII型コラーゲン(COL17)を分子イメージングするという方法を用いた。本研究により、BP患者自己抗体がCOL17分子へ結合した際のCOL17分子の動態を直接視覚的に捉えることが可能となり、BP患者自己抗体によるCOL17に対する直接的病原性有無の解明のほか、自己抗体により切断されたCOL17断片の生理学的機能などを解明することが可能となる。

  • Research Products

    (9 results)

All 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Ectodomain shedding generates neoepitopes on collagen XVII, the major autoantigen for bullous pemphigoid.2010

    • Author(s)
      Nishie W, Lamer S, Schlosser A, Licarete E, Franzke C, Hofmann S, Jackow J, Sitaru C, Bruckner-Tuderman L.
    • Journal Title

      J Immunol 185

      Pages: 4938-4947

    • Peer Reviewed
  • [Journal Article] Circulating IgA and IgE autoantibodies in antilaminin-332 mucous membrane pemphigoid.2010

    • Author(s)
      atsuga K, Nishie W, Shinkuma S, Moriuchi R, Shibata M, Nishimura M, Hashimoto T, Shimizu H.
    • Journal Title

      Br J Dermatol 162

      Pages: 513-517

    • Peer Reviewed
  • [Journal Article] Complete paternal isodisomy of chromosome 17 in junctional epidermolysis bullosa with pyloric atresia.2010

    • Author(s)
      Natsuga K, Nishie W, Arita K, Shinkuma S, Nakamura H, Kubota S, Imakado S, Akiyama M, Shimizu H
    • Journal Title

      J Invest Dermatol 130

      Pages: 2671-2674

    • Peer Reviewed
  • [Journal Article] A novel humanized neonatal autoimmune blistering skin disease model induced by maternally transferred antibodies.2009

    • Author(s)
      Nishie W, Sawamura D, Natsuga K, Shinkuma S, Goto M, Shibaki A, Ujiie H, Olasz E, Yancey KB, Shimizu H.
    • Journal Title

      J Immunol 183

      Pages: 4088-4093

    • Peer Reviewed
  • [Journal Article] Dynamic Interactions of Epidermal Collagen XVII with the Extracellular Matrix : Laminin 332 as a Major Binding Partner.

    • Author(s)
      Nishie W, Kiritsi D, Nystrom A, Hofmann S, Bruckner-Tuderman L.
    • Journal Title

      Am J Pathol in press.

    • Peer Reviewed
  • [Presentation] Dynamics of shed ectodomain of collagen XVII on extracellular matrix2010

    • Author(s)
      Nishie, W, Bruckner-Tuderman L
    • Organizer
      Annual Meeting of the German and British Societies for Matrix Biology
    • Place of Presentation
      Frankfurt / Main Germany
    • Year and Date
      20100300
  • [Presentation] Role of distinctive proteins interacting with collagen XVII in extracellular matrix.2010

    • Author(s)
      Nishie W, Bruckner-Tuderman L.
    • Organizer
      The 35th Annual Meeting of the Japanese Society of Invesitigative Dermatology
    • Place of Presentation
      Wakayama
    • Year and Date
      2010-12-03
  • [Presentation] Novel cleavage sites and specific neoepitopes on shed ectodomain of collagen XVII/BP180: role in autoimmune blistering diseases.2010

    • Author(s)
      Nishie W, Lamer S, Schlosser A, Licarete E, Franzke CW, Hofmann SC, Jackow J, Sitaru C, Bruckner-Tuderman L.
    • Organizer
      The 41st Annual Meeting of the European Society for Dermatological Research
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2010-09-10
  • [Presentation] Transmembrane collagen XVII: ectodomain shedding generates neo-epitopes.2009

    • Author(s)
      Nishie W, Has C, Bruckner-Tuderman L.
    • Organizer
      Gordon Research Conference, Collagen
    • Place of Presentation
      New London, NH, USA
    • Year and Date
      2009-07-20

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Published: 2012-03-09   Modified: 2016-04-21  

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