2010 Fiscal Year Final Research Report
Development of molecular imaging probes for β-amyloid and tau in Alzheimer's disease
| Project/Area Number |
20689023
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
ONO Masahiro Kyoto University, 薬学研究科, 准教授 (80336180)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 放射性医薬品 / 造影剤 |
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| Research Abstract |
Alzheimer's disease (AD) is a neurodegenerative disease of the brain associated with irreversible cognitive decline, memory impairment, and behavioral changes. Postmortem brains of AD patients reveal neuropathologic features : the presence of senile plaques (SPs) and neurofibrillary tangles (NFTs), which contain β-amyloid proteins and highly phosphorylated tau proteins. In the present study, we successfully designed and synthesized several PET/SPECT imaging probes for in vivo detection of SPs and NFTs, and evaluated their utility as molecular imaging probes for SPs and NFTs.
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