Genomewide association study on joint destruction in rheumatoid arthritis patients

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20689029
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: IKARI Katsunori Tokyo Women's Medical University, 医学部, 講師 (80343557)
• Project Period (FY): 2008 – 2011
• Keywords: リウマチ病学 / ゲノム

Research Abstract

ゲノムワイド関連解析(GWAS)を用いて関節リウマチ(RA)の疾患重症化に関連する遺伝子を同定する。さらに同定された重症化関連遺伝子群の遺伝子型と臨床指標の組み合わせに基づく表現型予測アルゴリズムを作成し、オーダーメイド医療に向けた基盤技術の整備を進める。

Research Products

• [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population. (2011)
  • Author(s): Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K.
  • Journal Title: Arthritis Rheum. 62(2) Pages: 574-579
  • Peer Reviewed
• [Journal Article] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. (2011)
  • Author(s): Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S
  • Journal Title: Ann Rheum Dis 69(2) Pages: 368-373
  • Peer Reviewed
• [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. (2010)
  • Author(s): Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K.
  • Journal Title: Nat Genet. 42(6) Pages: 515-519
  • Peer Reviewed
• [Journal Article] Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients. (2008)
  • Author(s): Nishimoto K, Ikari K, Mochizuki T, Tomatsu T, Toyama Y, Hara M, Yamanaka H, Kamatani N, Momohara S.
  • Journal Title: Ann Rheum Dis. 67(3) Pages: 431-432
  • Peer Reviewed
• [Journal Article] Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. (2008)
  • Author(s): Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S
  • Journal Title: .Arthritis Rheum. 58(7) Pages: 1940-1946
  • Peer Reviewed
• [Remarks] ホームページアドレス
  • URL: http://www.twmu.ac.jp/IOR