2010 Fiscal Year Final Research Report
Corneal regeneration using epithelial, stromal, and endothelial precursor cells based on cellular senescence control
| Project/Area Number |
20689032
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIMURA Tatsuya The University of Tokyo, 研究員 (70463867)
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| Co-Investigator(Renkei-kenkyūsha) |
USUI Tomohiko 東京大学, 大学院・医学研究科, 講師 (80282557)
HONDA Norihiko 東京大学, 大学院・医学研究科, 大学院生
YOKOO Seiichi 東京大学, 大学院・医学研究科, 助教 (20345052)
YAMAGAMI Satoru 東京大学, 大学院・医学研究科, 助教授 (10220245)
AMANO Shiro 東京大学, 大学院・医学研究科, 教授 (80193027)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 眼発生 / 再生医学 / 角膜再生 / 幹細胞移植 / 老化制御 / 臨床試験 |
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| Research Abstract |
We developed an adult stem cell=precursor cell isolation method (the sphere-forming assay) for corneal epithelial, stromal, and endothelial cells, which could isolate cells with differences of telomere length, telomerase activity, and characteristics reflecting senescence. We demonstrated transplantation of corneal epithelial sheet using epithelial precursors, stromal sheet using keratocyte precursors combined with gelatin hydrogel, or spheres of endothelial precursors to the cornea is a possible treatment strategy for corneal regeneration.
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[Journal Article] In vivo confocal microscopy of hereditary sensory and autonomic neuropathy.2008
Author(s)
Mimura T, Amano S, Fukuoka S, Honda N, Arita R, Ochiai M, Yanagisawa M, Usui T, Ono K, Araki F, Yamagami S, Araie M, Awaya Y.
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Journal Title
Curr Eye Res. 33(11)
Pages: 940-945
Peer Reviewed
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