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2010 Fiscal Year Final Research Report

Taste receptor : a new therapeutic target for obesity and diabetes

Research Project

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Project/Area Number 20689034
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionKyushu University

Principal Investigator

SHIGEMURA Noriatsu  Kyushu University, 歯学研究院, 准教授 (40336079)

Project Period (FY) 2008 – 2010
Keywords味覚 / うま味 / 遺伝子多型性 / 受容体 / 臓器 / ヒト / 肥満
Research Abstract

Umami taste is elicited by L-glutamate, and is thought to be one of five basic taste qualities that plays a key role in intake of amino acids. A heterodimer of a G protein coupled receptor, T1R1 and T1R3, is proposed to function as its receptor. However, little is known about single nucleotide polymorphisms (SNP) in the genes and its potential links with individual differences in umami sensitivity. Here we investigated the association between recognition thresholds for umami substances and genetic variations in human T1R1 and T1R3, and the functions of T1R1/T1R3 variants using a heterologous expression system. Our study demonstrated that the T1R1-372Thr creates a more sensitive umami receptor than -372Ala, while T1R3-757Cys creates a less sensitive one than -757Arg for umami substances, and showed a strong correlation between the recognition thresholds and in vitro dose-response relationships. These results in human studies support the propositions that a T1R1/T1R3 heterodimer acts as an umami receptor, and that genetic variation in this heterodimer directly affects umami taste sensitivity.

  • Research Products

    (31 results)

All 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (12 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Taste preference for fatty acids is mediated by GPR40andGPR120.2010

    • Author(s)
      Cartoni C, Yasumatsu K, Ohkuri T, Shigemura N, Yoshida R, Godinot N, le Coutre J, Ninomiya Y, Damak S.
    • Journal Title

      JNeurosci. 30(25)

      Pages: 8376-8382

    • Peer Reviewed
  • [Journal Article] Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors.2010

    • Author(s)
      Jyotaki M, Shigemura N, Ninomiya Y.
    • Journal Title

      Endocr J. 57(6)

      Pages: 467-475

    • Peer Reviewed
  • [Journal Article] New frontiers ingut nutrient sensor research: nutrient sensors in the gastrointestinal tract: modulation of sweet taste sensitivity by leptin.2010

    • Author(s)
      Horio N, Jyotaki M, Yoshida R, Sanematsu K, Shigemura N, Ninomiya Y.
    • Journal Title

      J Pharmacol Sci. 112(1)

      Pages: 8-12

    • Peer Reviewed
  • [Journal Article] Endocannabinoids selectively enhance sweet taste.2010

    • Author(s)
      Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y.
    • Journal Title

      Proc Natl Acad Sci USA. 107(2)

      Pages: 935-939

    • Peer Reviewed
  • [Journal Article] Genetically-increased taste cell population with G(alpha)-gustduc in-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in mice.2009

    • Author(s)
      Yasumatsu K, Ohkuri T, Sanematsu K, Shigemura N, Katsukawa H, Sako N, Ninomiya Y.
    • Journal Title

      BMC Neurosci. 10

      Pages: 152

    • Peer Reviewed
  • [Journal Article] Genetic and molecular basis of individual differences in human umami taste perception.2009

    • Author(s)
      Shigemura N, Shirosaki S, Sanematsu K, Yoshida R, Ninomiya Y.
    • Journal Title

      PLoS One. 4(8)

      Pages: e6717

    • Peer Reviewed
  • [Journal Article] Modulation and transmission of sweet taste information for energy homeostasis.2009

    • Author(s)
      Sanematsu K, Horio N, Murata Y, Yoshida R, Ohkuri T, Shigemura N, Ninomiya Y.
    • Journal Title

      Ann N Y Acad Sci. 1170

      Pages: 102-106

    • Peer Reviewed
  • [Journal Article] Multiple receptor systems for umami taste in mice.2009

    • Author(s)
      Yoshida R, Yasumatsu K, Shirosaki S, Jyotaki M, Horio N, Murata Y, Shigemura N, Nakashima K, Ninomiya Y.
    • Journal Title

      Ann N Y Acad Sci. 1170

      Pages: 51-54

    • Peer Reviewed
  • [Journal Article] Variation in umami perception and in candidate genes for the umami receptor in mice and humans.2009

    • Author(s)
      Shigemura N, Shirosaki S, Ohkuri T, Sanematsu K, Islam AA, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y.
    • Journal Title

      Am J Clin Nutr. 90(3)

      Pages: 764S-769S

    • Peer Reviewed
  • [Journal Article] Discrimination of taste qualities among mouse fungiform taste bud cells.2009

    • Author(s)
      Yoshida R, Miyauchi A, Yasuo T, Jyotaki M, Murata Y, Yasumatsu K, Shigemura N, Yanagawa Y, Obata K, Ueno H, Margolskee RF, Ninomiya Y.
    • Journal Title

      J Physiol. 587(Pt18)

      Pages: 4425-4439

    • Peer Reviewed
  • [Journal Article] Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion.2009

    • Author(s)
      Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I.
    • Journal Title

      PLoS One. 4(4)

      Pages: e5106

    • Peer Reviewed
  • [Journal Article] NaCl responsive taste cells in the mouse fungiform taste buds.2009

    • Author(s)
      Yoshida R, Horio N, Murata Y, Yasumatsu K, Shigemura N, Ninomiya Y.
    • Journal Title

      Neuroscience. 159(2)

      Pages: 795-803

    • Peer Reviewed
  • [Journal Article] Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels.2008

    • Author(s)
      Nakamura Y, Sanematsu K, Ohta R, Shirosaki S, Koyano K, Nonaka K, Shigemura N, Ninomiya Y.
    • Journal Title

      Diabetes. 57(10)

      Pages: 2661-2665

    • Peer Reviewed
  • [Presentation] Single nucleotide polymorphisms(SNPs)in taste sensor genes and perceptual diversity.2010

    • Author(s)
      Shigemura N, Ogiwara Y, Sanematsu K, Kawai M, Yoshida R, Ninomiya Y.
    • Organizer
      87th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Iwate, Japan
    • Year and Date
      2010-05-21
  • [Presentation] ヒトうま味感受性の多様性における遺伝・分子学的基盤2010

    • Author(s)
      重村憲徳、城崎慎也、實松敬介、吉田竜介、二ノ宮裕三
    • Organizer
      第8回口腔医科学フロンティア学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-03-06
  • [Presentation] 味覚と肥満2009

    • Author(s)
      重村憲徳
    • Organizer
      日本咀嚼学会第20回記念学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-03
  • [Presentation] Functional analysis of TAS1R1/TAS1R3 umami rtaste eceptor variants.2009

    • Author(s)
      Shigemura N, Shirosaki S, Sanematsu K, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y.
    • Organizer
      32th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2009-09-17
  • [Presentation] 味覚センサーの特性と多様性:うま味感受性の個体差と受容体遺伝子多型2009

    • Author(s)
      二ノ宮裕三、重村憲徳
    • Organizer
      第51回歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
  • [Presentation] ヒトうま味感受性の多様性における遺伝・分子学的基盤2009

    • Author(s)
      重村憲徳
    • Organizer
      日本味と匂学会第43回大会
    • Place of Presentation
      旭川
    • Year and Date
      2009-09-03
  • [Presentation] Functional expression study of TAS1R1/TAS1R3 receptor variants associated with individual differences in human umami taste sensitivity.2009

    • Author(s)
      Shigemura N, Shirosaki S, Sanematsu K, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y.
    • Organizer
      36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-31
  • [Presentation] Genitic and Molecular Basis of Indivisual Differences in human Umami Taste Perception2009

    • Author(s)
      Shigemura N, Shirosaki S, Sanematsu K, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y.
    • Organizer
      31th Annual Meeting of the Association for Chemoreception Sciences
    • Place of Presentation
      Sarasota, USA
    • Year and Date
      2009-04-24
  • [Presentation] Relationship between individual differences in umami taste sensitivity and genetic variations of T1r1 and T1r3 in human2008

    • Author(s)
      Shigemura N, Shirosaki S, Sanematsu K, Shahidal AA Islam, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y.
    • Organizer
      6th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-12-06
  • [Presentation] ヒトうま味感受性の多様性とうま味受容体遺伝子多型性との相関2008

    • Author(s)
      重村憲徳、イスラムアブ、城崎慎也、實松敬介、荻原葉子、河合美佐子、吉田竜介、二ノ宮裕三
    • Organizer
      日本味と匂学会第42回大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-18
  • [Presentation] Relationship between individual differences in umami taste sensitivity and genetic variations of T1rs and mGluRs in human2008

    • Author(s)
      Shigemura N
    • Organizer
      100th anniversary symposium of umami discovery, International Glutamate Technical Committee
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-09-11
  • [Presentation] Genetic alteration of gurmarin sensitivity is associated with formation of both receptor and neural system for sweet taste in mice.2008

    • Author(s)
      Shigemura N, Yasuo T, Shirosaki S, Yasumatsu K, Katsukawa H, Imoto T, Sako N, Ninomiya Y.
    • Organizer
      International Symposium on Olfaction and Taste
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-07-22
  • [Book] 医学のあゆみ「味覚受容体の構造と機能の多様性」233(9) 2902010

    • Author(s)
      重村憲徳、二ノ宮裕三
    • Total Pages
      875-880
    • Publisher
      医歯薬出版株式会社
  • [Book] 実験医学「内因性カンナビノイドの甘味増強作用」 28(9) 1362010

    • Author(s)
      田竜介、大栗弾宏、重村憲徳、二ノ宮裕三
    • Total Pages
      1405-1408
    • Publisher
      羊土社
  • [Book] オンラインジャーナルTeamApproachスペシャル特集:糖尿病と歯科疾患の密接な関係「肥満糖尿病と味覚」2009

    • Author(s)
      重村憲徳、二ノ宮裕三
    • Publisher
      ネイチャージャパン株式会社
    • URL

      http://www.team-approach.net/myaccount/login.php?forward=/tokushu/article.php?id=50

  • [Book] ANTI-AGINGMEDICINE「味覚の新知見」vol.4-5 1362008

    • Author(s)
      重村憲徳、二ノ宮裕三
    • Total Pages
      14-18
    • Publisher
      メディカルビュー社
  • [Book] アンチエイジング医学の基礎と臨床:「味覚とアンチエイジング」2008

    • Author(s)
      重村憲徳、二ノ宮裕三
    • Total Pages
      364-366
    • Publisher
      メディカルビュー社
  • [Remarks] ホームページ等

    • URL

      http://www.dent.kyushu-u.ac.jp/sosiki/a06/index.html

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Published: 2012-02-13   Modified: 2016-04-21  

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