2009 Fiscal Year Final Research Report
Functional analysis of small G protein Rac1 and Rac3 signalings during corticogenesis
| Project/Area Number |
20700289
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Kobe University |
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Principal Investigator |
KASSAI Hidetoshi Kobe University, 大学院・医学系研究科, 助教 (40403232)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子 / 細胞神経科学 |
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| Research Abstract |
Rac1 and Rac3 are highly homologous proteins, and it has been quite difficult to analyze their functions separately. Here I generated the knock-in mice, in which express epitope-tagged Rac3 so that Rac1 and Rac3 are easily distinguished at the protein level. By using these knock-in mice, expression patterns of Rac1 and Rac3 are traced in the developing brains. Also, proteomic analysis of Rac3 complex was performed to clarify Rac3 signaling in the brain. I identified several proteins which specifically associate with activated Rac3.
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