Dendrite targeting mechanism in neurons.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20700296
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Keio University
• Principal Investigator: MATSUDA Shinji Keio University, 医学部, 講師 (60321816)
• Project Period (FY): 2008 – 2010
• Keywords: 神経細胞 / 極性輸送 / AMPA受容体 / TARPアダプタータンパク質 / エンドサイトーシス / シナプス可塑性

Research Abstract

We indicated that the AP-4 deficient mice, which induces AMPA receptor mislocalization, showed abnormalities on the motor learning and anxiety behavior. Our electrophysiological analysis also indicated that the cerebellar LTP was impaired.
We also indicated that the AMPA receptors bind to AP-2 and AP-3A via TARP. These interactions are regulated by the phosphorylation of TARPs.

Research Products

• [Journal Article] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum (2009)
  • Author(s): Matsuda K, Kondo T, Iijima T, Matsuda S, Watanabe M, Yuzaki M
  • Journal Title: EUROPEAN JOURNAL OF NEUROSCIENCE 29 Pages: 707-717
  • Peer Reviewed
• [Journal Article] Polarized sorting of AMPA receptors to the somatodendritic domain is regulated by adaptor protein AP-4 (2009)
  • Author(s): Matsuda S, Yuzaki M
  • Journal Title: NEUROSCIENCE RESEARCH 65 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Accumulation of AMPA receptor in autophagosomes in neuronal axons lacking adaptor protein AP-4. (2008)
  • Author(s): Matsuda, S., Miura, E., Matsuda, K., Kakegawa, W., Kohda, K., Watanabe, M., Yuzaki, M.
  • Journal Title: Neuron 57 Pages: 730-745
  • Peer Reviewed
• [Journal Article] AP-4: autophagy-four mislocalized proteins in axons (2008)
  • Author(s): Matsuda S, Yuzaki M
  • Journal Title: Autophagy 4 Pages: 815-816
• [Journal Article] 神経における極性輸送 (2008)
  • Author(s): 松田信爾、柚崎通介
  • Journal Title: 蛋白質核酸酵素 53 Pages: 2214-2219
• [Presentation] New mechanisms regulating the number of AMPA receptors at synapses (2009)
  • Author(s): Michisuke Yuzaki, Shinji Matsuda柚崎通介、松田信爾
  • Organizer: 第32回日本神経科学大会(Neuro2009)
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-18
• [Presentation] Mechanisms for polarized sorting of glutamate receptors to the somatodendritic domain of neurons (2008)
  • Author(s): 松田信爾、三浦会里、掛川渉、松田恵 子、幸田和久、渡辺雅彦、柚崎通
  • Organizer: 第31回日本神経科学大会(Neuro2008)
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11
• [Presentation] Regulation of autophagy in neuronal axons (2008)
  • Author(s): 柚崎通介、西山潤、松田信爾、三浦絵里子、水島昇、渡辺雅彦
  • Organizer: 第31回日本神経科学大会(Neuro2008)
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11