2009 Fiscal Year Final Research Report
Asymmetric endocytosis across the growth cone drives repulsive axon guidance
| Project/Area Number |
20700302
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TOJIMA Takuro The Institute of Physical and Chemical Research, 神経成長機構研究チーム, 研究員 (00373332)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 神経成長円錐 / 軸索ガイダンス / クラスリン依存性エンドサイトーシス / ダイナミン1 / カルシウム / カルシニューリン / 全反射蛍光顕微鏡法 / ケージド化合物光解離法 |
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| Research Abstract |
The neuronal growth cone navigates the axon along the correct path by sensing extracellular attractive and repulsive guidance cues. In this project, we investigated a driving mechanism of growth cone repulsion. We showed that the activity of clathrin-mediated endocytosis becomes polarized in growth cones and that such asymmetry in endocytosis is required and sufficient for repulsive growth cone guidance.
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Research Products
(15 results)
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[Journal Article] DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death.2009
Author(s)
Kenji Amano, Morimitsu Fujii, Satoru Arata, Takuro Tojima, Masaharu Ogawa, Noriyuki Morita, Atsushi Shimohata, Teiichi Furuichi, Shigeyoshi Itohara, Hiroyuki Kamiguchi, Julie Korenberg, Akiko Arata, Kazuhiro Yamakawa
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Journal Title
Journal of Neuroscience 29
Pages: 2984-2996
Peer Reviewed
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