2010 Fiscal Year Final Research Report
Developmental analysis of neuronal networks in the brain using X-ray nano-tomography
| Project/Area Number |
20700314
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIZUTANI Haruo The University of Tokyo, 総括プロジェクト機構, 特任助教 (40444103)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経回路網 / X線イメージング |
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| Research Abstract |
Neural circuits in the central nervous system are the substrate of various high-order brain functions. Here, we aim to develop a three-dimensional mouse brain atlas of neural circuits using high resolution X-ray microscopy by synchrotron radiation. In this study, a nano-resolution full-field X-ray microscopy revealed synapses in the mouse cerebral cortex. Moreover, phase contrast X-ray tomography unveiled 3D structure of the mouse brain tissue with isometric nano-meter voxel sizes. In the near future, we will utilize that information to begin deciphering the wiring diagram of the developing brain by applying the nano-resolution X-ray microscopy.
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