Functional analysis of Disrupted-in-schizophrenia 1 (DISC1)

2009 Fiscal Year Final Research Report

• Project/Area Number: 20700333
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagoya University
• Principal Investigator: TAYA Shinichiro Nagoya University, 神経研究所・診断研究部, 室長 (60362232)
• Project Period (FY): 2008 – 2009
• Keywords: 精神 / 神経疾患の病態と治療

Research Abstract

Schizophrenia is a disease affecting about 1% of the population in the world. However, mpathogenesis of schizophrenia is unclear, several hypotheses are reported. To understand molecular level of schizophrenic pathogenesis, I focused on DISC1 and its interacting molecules. In this study, I showed that DISC1 and its interacting molecules regulate axon elongation, synapse formation, and neuronal migration. These results suggest that the functional analysis of DISC1 leads to molecular level of schizophrenic pathogenesis.

Research Products

• [Journal Article] Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: an in vivo microdialysis study. (2010)
  • Author(s): Nagai T, Kitahara Y, Shiraki A, Hikita T, T a y a S, Kaibuchi K, Yamada K
  • Journal Title: Neuroscience Letter 470 Pages: 134-138
  • Peer Reviewed
• [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. (2009)
  • Author(s): Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, T a y a S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M
  • Journal Title: Neuron 63 Pages: 774-787
  • Peer Reviewed
• [Journal Article] Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein. (2009)
  • Author(s): Hikita T, T a y a S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K
  • Journal Title: Journal of Neurochemistry 110 Pages: 1567-1574
  • Peer Reviewed
• [Journal Article] Association analysis between schizophrenia and the AP-3 complex genes. (2009)
  • Author(s): Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, T a y a S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H
  • Journal Title: Neuroscience Research 65 Pages: 113-115
  • Peer Reviewed
• [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. (2009)
  • Author(s): Arimura N, Kimura T, Nakamuta S, T a y a S, Funahashi Y, Hattori A, Shimada A, Menager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K
  • Journal Title: Developmental Cell 16 Pages: 675-686
  • Peer Reviewed
• [Journal Article] Direct interaction of Dysbindin with the AP-3 complex via its mu subunit. (2009)
  • Author(s): Taneichi-Kuroda S, T a y a S, Hikita T, Fujino Y, Kaibuchi K
  • Journal Title: Neurochemical International 54 Pages: 431-438
  • Peer Reviewed
• [Presentation] 統合失調症関連因子DISC1は分子の輸送に関与し、軸索伸長を制御する (2009)
  • Author(s): 田谷真一郎、浦口淳子、黒田啓介、坪井大輔、貝淵弘三
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋市名古屋国際会議場
  • Year and Date: 20090602-20090604
• [Presentation] Risk factors for schizophrenia and their physiological functions (2008)
  • Author(s): 田谷真一郎、貝淵弘三
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 20080709-20080711
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/Yakuri/