2009 Fiscal Year Final Research Report
Mechanisms of lipid raft disturbance and role of raft-related neurogenerational molecules in the GM3 only mice
| Project/Area Number |
20700342
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Chubu University |
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Principal Investigator |
TAJIMA Orie Chubu University, 生命健康科学部, 准教授 (10362237)
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| Project Period (FY) |
2008 – 2009
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| Keywords | スフィンゴ糖脂質 / ノックアウト / 神経変性 / ラフト / 中枢神経 / ガングリオシド / 神経再生分子 |
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| Research Abstract |
In the brain of the GM3 only mice that defected normal gangliosides composition, localization of lipid raft proteins shifted to non-raft region with aging. Ninjurin2, reported as one of the neuroregeneration-related molecules, was down-regulated in the GM3 only mice in central nervous system. Ninjurin2 localized at raft region and related to homophilic cell adhesion and increased neurite outgrowth. These date suggested that disturbance of raft compositions accelerate neurodegeneration in the GM3 only mice.
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[Journal Article] Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging.2009
Author(s)
Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki K, Fujiwara M, Inokuchi J, Sugiura Y, Furukawa K, Furukawa K.
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Journal Title
Behav Brain Res 198
Pages: 74-82
Peer Reviewed
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[Journal Article] Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: Sensitivity analysis with glycosylation-defective mutant mice.2009
Author(s)
Kondo Y, Tokuda N, Fan X, Yamashita T, Honke K, Takematsu H, Togayachi A, Ohta M, Kotzusumi Y, Narimatsu H, Tajima O, Furukaw K, Furukawa K.
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Journal Title
Biochem Biophys Res Commun 378
Pages: 179-81
Peer Reviewed
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