2009 Fiscal Year Final Research Report

Study on the channel-gating mechanism of the inositol-trisphosphate receptor

Research Project

Project/Area Number	20700344
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Neurochemistry/Neuropharmacology
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	ENOMOTO Masahiro The Institute of Physical and Chemical Research, 発生神経生物研究チーム, 基礎科学特別研究員 (50435632)
Project Period (FY)	2008 – 2009
Keywords	神経科学 / 受容体 / イオンチャネル / 細胞内カルシウム情報伝達 / カルシウム放出
Research Abstract	I have achieved the following outstanding outcomes from this research project. One is that "the interaction between regulatory domain and channel domain of IP_3R directly regulates the open-close transition.", and another is that " IP_3-binding domain of IP_3R is essential for the IP_3-induced Ca^<2+> release function, and the mutant lacking in this region shows the character of Ca^<2+>-induced Ca^<2+> release channel." These results are highly-impact outcomes that have firstly in the world elucidated the basic channel-gating mechanism of IP_3R.

(1 results)