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2010 Fiscal Year Final Research Report

Elucidation of amygdala-hippocampal interaction mechanism under lying emotional memory

Research Project

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Project/Area Number 20700346
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionTohoku University

Principal Investigator

KARASHIMA Akihiro  東北大学, 大学院・情報科学研究科, 助教 (40374988)

Co-Investigator(Renkei-kenkyūsha) KATAYAMA Norihiro  東北大学, 大学院・情報科学研究科, 准教授 (20282030)
Project Period (FY) 2008 – 2010
Keywords海馬θ波 / レム睡眠 / 情動記憶 / ストレス / 逃避学習
Research Abstract

We recorded brainactivitiesin the hippocampus and amygdala, which are involved in memory and emotion,and investigated the time relationship between two brain activities.Theta wavein the amygdala was confirmed to besynchronized with theta wavein the hippocampus. In addition, we found that the synchronization was modulated by the pontine subcoeruleus region, which activates many brain areas including the hippocampus and amygdala.Because hippocampal and amygdalatheta waves are known to be involved in learning and memory processes, these results may help clarify these functions during REM sleep.

  • Research Products

    (32 results)

All 2011 2010 2009 2008

All Journal Article (20 results) (of which Peer Reviewed: 7 results) Presentation (11 results) Book (1 results)

  • [Journal Article] 睡眠中の情報処理機構と神経回路網の再編成2011

    • Author(s)
      辛島彰洋、片山統裕、中尾光之
    • Journal Title

      睡眠医療

      Volume: 4巻 Pages: 469-475

  • [Journal Article] Enhancement of synchronization between hippocampal and amygdala theta waves associated with pontine wave density2010

    • Author(s)
      A. Karashima, N. Katayama, M. Nakao
    • Journal Title

      Journal of Neurophysiology

      Volume: 103巻 Pages: 2318-2325

    • Peer Reviewed
  • [Journal Article] Top-down modeling of hierarchical biological clock mechanisms2010

    • Author(s)
      M. Nakao, H. Okayama, A. Karashima, N. Katayama
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 8巻 Pages: 106-113

    • Peer Reviewed
  • [Journal Article] 聴性脳幹反応の睡眠-覚醒状態依存性におけるアセチルコリンの役割2010

    • Author(s)
      深澤孝浩、大久保博文、辛島彰洋、片山統裕、中尾光之
    • Journal Title

      信学技報(MBE)

      Volume: 110巻 Pages: 11-14

  • [Journal Article] ヒトにおける眠気と聴覚応答の関係2010

    • Author(s)
      安井洋介、辛島彰洋、中谷浩人、大久保博文、片山統裕、中尾光之
    • Journal Title

      信学技報(MBE)

      Volume: 110巻 Pages: 1-4

  • [Journal Article] 多点細胞外活動電位を利用したニューロン位置推定法の計算機実験に基づく評価2010

    • Author(s)
      孫昊、片山統裕、白石泰士、辛島彰洋、中尾光之
    • Journal Title

      信学技報(MBE)

      Volume: 110巻 Pages: 5-10

  • [Journal Article] Modeling of segmentation clock mechanism in presomitic mesoderm2009

    • Author(s)
      A. Kazama, A. Karashima, N. Katayama, M. Nakao
    • Journal Title

      Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society

      Volume: 1巻 Pages: 3267-3270

    • Peer Reviewed
  • [Journal Article] Multi-neuron action potentials recorded with tetrode are not instantaneous mixtures of single neuronal action potentials2009

    • Author(s)
      Y. Shiraishi, N. Katayama, T. Takahashi, A. Karashima, M. Nakao
    • Journal Title

      Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society

      Volume: 1巻 Pages: 4019-4022

    • Peer Reviewed
  • [Journal Article] 睡眠時の振動的神経活動とその機能2009

    • Author(s)
      辛島彰洋、岩崎直穂子、片山統裕、中尾光之
    • Journal Title

      生体の科学

      Volume: 60巻 Pages: 295-302

  • [Journal Article] 活性化レベルの長期的変容による皮質神経回路網の再編成と睡眠時脳波ダイナミクス2009

    • Author(s)
      辛島彰洋、岩崎直穂子、片山統裕、中尾光之
    • Journal Title

      感性福祉研究所年報

      Volume: 10巻 Pages: 15-20

  • [Journal Article] ヒト睡眠・覚醒リズムのユーティリティモデルを作る2009

    • Author(s)
      中尾光之、石浦大樹、辛島彰洋、片山統裕、
    • Journal Title

      時間生物学

      Volume: 15巻 Pages: 40-49

  • [Journal Article] マウス視床皮質スライスの多点電位記録によるシナプス応答の解析2009

    • Author(s)
      荒井香、片山統裕、白石泰士、辛島彰洋、中尾光之
    • Journal Title

      信学技報(MBE)

      Volume: 109巻 Pages: 3-6

  • [Journal Article] ノンレム睡眠およびレム睡眠期の体性感覚応答2009

    • Author(s)
      稲田浩之、辛島彰洋、片山統裕、中尾光之
    • Journal Title

      信学技報(MBE)

      Volume: 109巻 Pages: 7-12

  • [Journal Article] 1計測信号参照系独立成分分析法のシミュレーション研究2009

    • Author(s)
      幡谷速昭、木村芳孝、伊藤拓哉、辛島彰洋、片山統裕、八重樫伸生、中尾光之
    • Journal Title

      信学技報(MBE)

      Volume: 109巻 Pages: 37-40

  • [Journal Article] A Topographic Analysis of Human Scalp Alpha EEG by the Complex-valued ICA2009

    • Author(s)
      Z. Zhang, N. Katayama, K. Watanabe, H. Nakatani, A. Karashima, M. Nakao
    • Journal Title

      信学技報(MBE)

      Volume: 109巻 Pages: 41-46

  • [Journal Article] 複素独立成分分析を用いたニューロン活動電位のハードリアルタイム弁別システム2009

    • Author(s)
      白石泰士、片山統裕、高橋哲也、辛島彰洋、中尾光之
    • Journal Title

      信学技報(NC)

      Volume: 109巻 Pages: 1-6

  • [Journal Article] Progressive changes in sleep electroencephalogram dynamics in the rat barrel cortex associated with long-term alternation of sensory input activities2008

    • Author(s)
      N. Iwasaki, A. Karashima, N. Katayama, M. Nakao
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 6巻 Pages: 208-214

    • Peer Reviewed
  • [Journal Article] 神経スパイクの相互相関解析を利用したシナプス結合強度のモデルベース推定法2008

    • Author(s)
      菊池修、片山統裕、辛島彰洋、中尾光之
    • Journal Title

      生体医工学

      Volume: 46巻 Pages: 667-674

    • Peer Reviewed
  • [Journal Article] 複数ニューロン記録用多重電極の設計支援を志向した3次元神経組織モデルの構築2008

    • Author(s)
      久保貴嗣、片山統裕、辛島彰洋、中尾光之
    • Journal Title

      生体医工学

      Volume: 46巻 Pages: 675-683

    • Peer Reviewed
  • [Journal Article] 細胞外活動電位の多点記録に基づくニューロンの3次元位置推定法2008

    • Author(s)
      久保貴嗣、片山統裕、辛島彰洋、中尾光之
    • Journal Title

      信学技報(MBE)

      Volume: 108巻 Pages: 21-24

  • [Presentation] Effect of pontine wave on hippocampal and amygdala theta synchronization during REM sleep2010

    • Author(s)
      A. Karashima, N. Katayama, M. Nakao
    • Organizer
      20th Congress of the European Sleep Research Society
    • Place of Presentation
      リスボン市(スペイン)
    • Year and Date
      2010-09-16
  • [Presentation] 睡眠-覚醒制御機構の数理モデル2010

    • Author(s)
      辛島彰洋、片山統裕、中尾光之
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-07-01
  • [Presentation] Effect of NREM and REM sleep on somatosensory evoked potentials in rat2010

    • Author(s)
      A. Karashima, H. Inada, N. Katayama, M. Nakao
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-21
  • [Presentation] Enhancement of synchronization between hippocampal and amygdala theta waves associated with pontine wave density2009

    • Author(s)
      A. Karashima, N. Katayama, M. Nakao
    • Organizer
      The 1st ASRS Summit and Symposium of Asia Oceania Sleep research and Sleep medicine in Okinawa
    • Place of Presentation
      沖縄県名護市
    • Year and Date
      2009-11-01
  • [Presentation] Role of P wave in amygdala and hippocampal theta synchronization during REM sleep in rats2009

    • Author(s)
      A. Karashima, N. Katayama, M. Nakao
    • Organizer
      The 6th Congress of Asian Sleep Research Society
    • Place of Presentation
      大阪市
    • Year and Date
      2009-10-26
  • [Presentation] 聴性脳幹反応の潜時の徐波位相依存性2009

    • Author(s)
      辛島彰洋、大久保博文、片山統裕、中尾光之
    • Organizer
      第24回生体・生理工学シンポジウム
    • Place of Presentation
      仙台市
    • Year and Date
      2009-09-26
  • [Presentation] Auditory brainstem response dependency on rapid eye movement sleep in rat2009

    • Author(s)
      A. Karashima, H. Okubo, N. Katayama, M. Nakao
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-09-18
  • [Presentation] Effect of sleep on auditory evoked potential2009

    • Author(s)
      A. Karashima, H. Okubo, N. Katayama, H. Nakatani, M. Nakao
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-08-01
  • [Presentation] Synchronization of amygdala and hippocampal theta rhythm during REM sleep in rats2008

    • Author(s)
      A. Karashima, N. Katayama, M. Nakao
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Place of Presentation
      アメリカワシントンD. C.
    • Year and Date
      2008-11-17
  • [Presentation] Long-term sensory deprivation causes local change in slow wave activity during NREM sleep2008

    • Author(s)
      A. Karashima, N. Katayama, M. Nakao
    • Organizer
      日本神経科学学会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2008-07-09
  • [Presentation] スパイク相関解析法を用いた縫線核局所神経回路の研究2008

    • Author(s)
      辛島彰洋、嶋崎統彦、片山統裕、中尾光之
    • Organizer
      日本睡眠学会第33回定期学術集会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2008-06-25
  • [Book] Neural modeling for cooperative/competitive regulation of REM sleep with NREM sleep and wakefulness, 「Rapid Eye Movement Sleep : Regulation and Function,(Eds. B.N. Mallick, S.R. Pandi-Perumal, R.W. McCarley, A. Morrison)の第43章」2011

    • Author(s)
      A. Karashima, Y. Tamakawa, Y. Koyama, N. Katayama, M. Nakao
    • Total Pages
      437-449
    • Publisher
      Cambridge University Press

URL: 

Published: 2013-07-31  

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