2009 Fiscal Year Final Research Report
Clarification of vasospasm by a spatiotemporal nanoscale analysis of signal molecules.
| Project/Area Number |
20700359
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KAWAMICHI Hozumi Yamaguchi University, 大学院・医学系研究科, 助教 (80363042)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 平滑筋生理 / 可視化 / 生体分子 / リアルタイム / 血管攣縮 |
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| Research Abstract |
Vasospasm is a Rho-kinase-mediated Ca^<2+>-independent abnormal contraction. However, its final step (= interaction of contractile proteins) was not determined yet. In this study, we developed a spatiotemporal nanoscale analysis of signal molecules, which were confirmed by mass spectrometry. Using this system, we found that even in the absence of Ca^<2+> smooth muscle myosin, whose regulatory light chains are phosphorylated by Rho-kinase, can show rapid sliding with actin at the maximum high speed.
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[Journal Article] Time Studies2008
Author(s)
Hozumi Kawamichi.
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Journal Title
Watching the motion pictures of signal molecules of the abnormal vascular contraction! Spatiotemporal nanoscale analysis of intracellular abnormality. 2
Pages: 45-64
Peer Reviewed
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