2009 Fiscal Year Final Research Report
Analysis of miRNA functions from miRNA knockout mouse
| Project/Area Number |
20700364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University |
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Principal Investigator |
HASUWA Hidetoshi Osaka University, 微生物病研究所, 助教 (50343249)
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| Project Period (FY) |
2008 – 2009
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| Keywords | マイクロRNA / 遺伝子改変動物 |
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| Research Abstract |
MicroRNAs (miRNAs) are endogenous small non-coding RNAs In mammals, the role of miRNAs is indicated in a few miRNAs, but the understanding of a relationship between the impairment of miRNA and diseases in animals is not clearly demonstrated. I tried to establish the miRNA knockout mouse and revealed that reproductive function was regulated by miRNA. Furthermore, I have clarified a real target gene related with phenotype using the miRNA knockout mouse.
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