2009 Fiscal Year Final Research Report
Establishment of noninvasive neuroimaging analysis in experimental animals by using diffusion weighted magnetic resonance imaging.
| Project/Area Number |
20700371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Fujita Health University |
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Principal Investigator |
YAMADA Masayuki Fujita Health University, 医療科学部, 准教授 (40383773)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 動物実験技術 |
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| Research Abstract |
The purpose of this study was to establish a noninvasive imaging analysis for detecting neural degeneration in the experimental animals by using magnetic resonance (MR) imaging. In this study, manganese enhanced MR imaging was optimized as a tool to depict the normal neural pathways in non-human primates in vivo. Furthermore, diffusion tensor MR imaging was performed to detect the degeneration on the retinal projection pathways of the animals. Results of this study suggest that diffusion weighted MR imaging is a useful tool for noninvasive neuroimaging analysis in the experimental animals.
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