2010 Fiscal Year Final Research Report
Development of biodegradable vascular grafts from salmon skin-derived elastic collagen
| Project/Area Number |
20700393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
NAGAI Nobuhiro Tohoku University, 大学院・医学系研究科, 助教 (30400039)
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| Co-Investigator(Renkei-kenkyūsha) |
MUNEKATA Masanobu 北海道大学, 大学院・工学研究科, 教授 (50261326)
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| Project Period (FY) |
2008 – 2010
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| Keywords | コラーゲン / 人工血管 / 再生医療 / サケ皮コラーゲン |
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| Research Abstract |
Elastic collagen tubes derived from salmon skin are promising vascular grafts. However, they have some drawbacks such as poor suturability and biodegradability. In this study, we investigated the improvements of mechanical strength and endothelial cell attachment of the collagen tubes by increasing the fibrillar density of collagen matrix, mixing polymers in the collagen matrix, and adsorbing fibronectin on the tubes.
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