2009 Fiscal Year Final Research Report
Preparation of novel drug-eluting stents with cell-compatibility and antithrombogenicity
| Project/Area Number |
20700395
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
YOSHIOKA Tomohiko Tokyo Institute of Technology, 大学院・理工学研究科, 助教 (50452016)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ステント / 金属酸化物 / 表面修飾 / シランカップリング剤 |
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| Research Abstract |
In this study, we focused on surface modification of Ni-free stainless-steel for novel drug-eluting stents with cell-compatibility. Ni-free stainless-steel was heated in order to control the composition of surface oxides. The surface composition was responsible for the immobilization of silane coupling agent, i.e., γ-aminopropyltriethoxysilane (APS). The APS immobilized surface adhered more human umbilical vein endothelial cells than a pristine surface.
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