Development of drug and gene delivery system for injured sites of cardiovascular tissues

2009 Fiscal Year Final Research Report

• Project/Area Number: 20700396
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: ISE Hirohiko Tokyo Institute of Technology, フロンティア研究センター, 特任講師 (10324253)
• Project Period (FY): 2008 – 2009
• Keywords: 薬物輸送システム / N-アセチルグルコサミン / レクチン / 糖鎖高分子

Research Abstract

Cardiomyocytes and vascular smooth muscle cells (VSMCs) were found to interact with N-acetylglucosamine (GlcNAc) using glycopolymers containing GlcNAc. It was assumed that these cells have GlcNAc-binding lectin on the cell surfaces. We tried to develop drug and delivery systems for injured site of cardiovascular tissue. The uptake of GlcNAc-conjugated liposomes to cardiomyocytes was observed. These results suggested the development of drug and gene delivery system for injured sites of cardiovascular tissues using GlcNAc-conjugated liposomes.

Research Products

• [Journal Article] Potential feasibility of early bone marrow cell injection into the spleen for creating functional hepatocytes. (2009)
  • Author(s): Misawa R, Soeda J, Ise H, Takahashi M, Kubota K, Mita A, Nakata T, Miyagawa S
  • Journal Title: Transplantation 87 Pages: 1147-1154
  • Peer Reviewed
• [Journal Article] Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy. (2009)
  • Author(s): Kobayashi S, Ise H, Takahashi M, Goto M, Akaike T, Ikeda U
  • Journal Title: Biomaterials 30 Pages: 574-582
  • Peer Reviewed
• [Journal Article] Vimentin and desmin possess GlcNAc-binding lectin-like properties on cell surfaces
  • Author(s): Ise H, Kobayashi S, Goto M, Sato T, Kawakubo M, Takahashi M, Ikeda U, Akaike T
  • Journal Title: Glycobiology (In press)
  • Peer Reviewed
• [Presentation] 人工糖鎖高分子PV-GlcNAcを用いた新規GlcNAc結合性レクチンの探索 (2009)
  • Author(s): 伊勢裕彦、後藤光昭、佐藤孝雄、赤池敏宏
  • Organizer: 第31回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-16
• [Presentation] TypeIII型中間径フィラメントのGlcNAc結合レクチン活性と細胞表面の発現 (2009)
  • Author(s): 伊勢裕彦、後藤光昭、佐藤孝雄、赤池敏宏
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] Development of a drug delivery system using N-acetylglucosamine-conjugated liposomes (2009)
  • Author(s): Ise H, Goto M, Akaike T
  • Organizer: The 7th Asia 3 (China-Japan-Korea) Foresight Symposium on Gene Therapy and Biomaterials
  • Place of Presentation: Korea, Seoul
  • Year and Date: 2009-05-25
• [Book] 医療・診断をめざす先端バイオテクノロジー関根光雄/編 (2009)
  • Author(s): 伊勢裕彦
  • Total Pages: 98-110
  • Publisher: 工学図書