2011 Fiscal Year Final Research Report
Development of a nanocarrier that can change its character responding to a tumor environment
| Project/Area Number |
20700400
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | 公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2008-2010) |
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Principal Investigator |
MATSUMURA Sachiko 公益財団法人がん研究会, がん研究所蛋白創製研究部, 研究員 (90414052)
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| Project Period (FY) |
2008 – 2011
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| Keywords | ドラッグデリバリー / ナノ粒子 / ペプチド / がん / 環境応答性 / マトリックスメタロプロテアーゼ / カーボンナノチューブ / フェリチン |
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| Research Abstract |
Nanoparticles are fascinating as a carrier for drugs and imaging agents. In this study, nanoparticles having responsivity to a tumor environment are constructed. Upon sensing an activity of enzyme, which is highly expressed in many types of tumors, the nanoparticles can obtain the ability to enter cells. Two kinds of nanoparticles, that is carbon-or protein-based ones, are studied.
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