Elucidation of the role of nitric oxide system in cardiac rehabilitation

2010 Fiscal Year Final Research Report

• Project/Area Number: 20700422
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: ITO Daisuke Tohoku University, 病院, 理学療法士 (50466570)
• Project Period (FY): 2008 – 2010
• Keywords: リハビリテーション医学 / 心臓リハビリテーション

Research Abstract

I examine the effects of the exercise training on nitric oxide(NO)system in chronic heart failure(CHF)model of rats. Exercise improved cardiac and renal function, and increased the expression of endothelial nitric oxide synthase(eNOS)and neuronal NOS(nNOS)in left ventricle and kidney of CHF rats. These findings suggest that the upregulation of the renal NO system may be a novel mechanism that could explain the beneficial effects of exercise training.

Research Products

• [Presentation] 慢性心不全ラットにおける心・腎nitric oxide合成酵素に対する長期的運動の影響 (2011)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戎栄, 下川宏明, 上月正博
  • Organizer: 第40回日本心脈管作動物質学会
  • Place of Presentation: 高松
  • Year and Date: 2011-02-04
• [Presentation] 慢性心不全ラットの血圧と心・腎nitric oxide合成酵素に対する長期的運動の影響 (2010)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戎栄, 下川宏明, 上月正博
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-16
• [Presentation] Effects of exercise training on nitric oxide synthases in rats with chronic heart failure. (2010)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M.
  • Organizer: 23rd Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Vancouver
  • Year and Date: 2010-09-28
• [Presentation] 慢性心不全モデルラットの心・腎NO合成酵素に対する長期的運動の影響 (2010)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戎栄, 下川宏明, 上月正博
  • Organizer: 第35回日本運動療法学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-07-03
• [Presentation] Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure. (2010)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Kohzuki M.
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications on Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-18