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2009 Fiscal Year Final Research Report

The effect of oxidative protein modification on impairment of energy metabolism in skeletal muscle with aging

Research Project

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Project/Area Number 20700525
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionKyoto Prefectural University

Principal Investigator

AOI Wataru  Kyoto Prefectural University, 生命環境科学研究科, 助教 (60405272)

Project Period (FY) 2008 – 2009
Keywords骨格筋 / エネルギー代謝 / 加齢 / 酸化ストレス / プロテオミクス / 蛋白質翻訳後修飾
Research Abstract

c57BL/6 mice kept with free access to chow and sedentary to old age show lipid accumulation and impairment of glucose tolerance as well as oxidative damage in skeletal muscle. In this study, we investigated oxidative protein modification in skeletal muscle associated with impairment of energy metabolism using the animal model as a model of glucose metabolism disorder. Consequently, it has been shown that nitration of tyrosine residues in adenylate kinase 1, which regulates intracellular AMP content, was increased. This may lead to the impairment of glucose uptake in skeletal muscle via lower activity of AMP-activated protein kinase in old mice.

  • Research Products

    (9 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (3 results)

  • [Journal Article] The microRNA miR-696 regulates PGC1alpha in mouse skeletal muscle in response to physical activity2010

    • Author(s)
      Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H, Yoshikawa T
    • Journal Title

      Am J Physiol Endocrinol Matab 298

      Pages: E799-E806

    • Peer Reviewed
  • [Journal Article] Dietary whey hydrolysate with exercise alters the plasma protein profile2010

    • Author(s)
      Aoi W, Takanami Y, Kawai Y, Morifuji M, Koga J, Kanegae M, Mihara K, Yanohara T, Mukai J, Naito Y, Yoshikawa T
    • Journal Title

      A comprehensive protein analysis, Nutrition (in press)

    • Peer Reviewed
  • [Journal Article] Relaxant effect of microtitan via regulation of autonomic nerve activity in mice2009

    • Author(s)
      Aoi W, Takanami Y, Kawai Y, Otsuki T, Kawake T, Naito Y, Yoshikawa T
    • Journal Title

      Life Sci 85

      Pages: 408-411

    • Peer Reviewed
  • [Presentation] 糖代謝不全マウスにおける骨格筋蛋白質の酸化的翻訳後修飾2009

    • Author(s)
      青井渉, 高波嘉一, 川合ゆかり, 市川寛, 吉川敏一
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-19
  • [Presentation] Exercise-induced oxidative CPT I modification and lipid metabolism in skeletal muscle2009

    • Author(s)
      Aoi W, Takanami Y, Kawai Y, Naito Y, Yoshikawa T
    • Organizer
      56th Amrican College of Sports Medicine
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2009-05-28
  • [Presentation] Astaxanthin improves muscle lipid metabolism in exercise2008

    • Author(s)
      Aoi W, Naito Y, Takanami Y, Kawai Y, Osawa T, Yoshikawa T, Takahashi J
    • Organizer
      15 th International Symposium on Carotenoids
    • Place of Presentation
      沖縄
    • Year and Date
      2008-06-24
  • [Book] Food factors for Health Promotion2009

    • Author(s)
      Aoi W
    • Total Pages
      147-155
    • Publisher
      KARGAR
  • [Book] スポーツ栄養・食事ガイド2009

    • Author(s)
      青井渉, 吉川敏一
    • Total Pages
      380-386
    • Publisher
      文光堂
  • [Book] アスタキサンチンの科学(担当部分:アスタキサンチンの抗疲労作用)2009

    • Author(s)
      青井渉
    • Total Pages
      60-70
    • Publisher
      成山堂書店

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Published: 2011-06-18   Modified: 2016-04-21  

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