2009 Fiscal Year Final Research Report
Improvement of insulin resistance by exercise in chronic hepatitis C patients
| Project/Area Number |
20700552
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Ehime University |
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Principal Investigator |
KONISHI Ichiro Ehime University, 医学系研究科, 講師 (30403801)
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| Project Period (FY) |
2008 – 2009
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| Keywords | C型肝炎ウイルス / 運動療法 / インスリン抵抗性 / 酸化ストレス / 内臓脂肪 / 糖尿病 / 慢性肝炎 / 肝硬変 |
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| Research Abstract |
We conducted a study to clarify whether walking combined with diet therapy improves insulin resistance and obesity in chronic hepatitis C (CH-C) patients. While body weight, body mass index and HOMA-IR decreased significantly during this study. On the other hand, liver functions did not get worse. In vitro, Hepatitis C virus (HCV) inhibited the uptake of glucose in the HCV infected cells. Aerobic exercise such as walking is useful to improve obesity and insulin resistance, and can be performed safely in CH-C patients.
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