2009 Fiscal Year Final Research Report

Plasma Proteome analysis of KK-Ay mice developing type-2 diabetes

Research Project

Project/Area Number	20700557
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Applied health science
Research Institution	Yamaguchi Prefectural University
Principal Investigator	KATO Motoshi Yamaguchi Prefectural University, 看護栄養学部, 助教 (60336930)
Project Period (FY)	2008 – 2009
Keywords	糖尿病 / 血漿 / プロテオーム解析 / KK-Ayマウス
Research Abstract	By performing plasma proteome analysis of KK-Ay mice, which are models of type 2 diabetes, we identified proteins that are specific to diabetes and its complications. We analyzed the mice at each stage of the pathological condition of the disease, wherein the symptoms worsened as the age (in weeks) of the mice increased. We thus identified several candidate plasma proteins that changed specifically with the progression of the disease. These proteins included Apolipoprotein E and the Fibrinogen gamma chain. The proteins identified in this study are indicators predicting the onset, development, and complications of diabetes, and are believed to contribute to early diagnosis and treatment.